Immune System Support Probiotics

Top 10 Best Probiotic Supplements for Digestive Support in 2022

ⓘ The rankings on Top10Supps are opinion only and not meant to replace professional advice or meant to be used to prevent, diagnose, or treat any disease or illness. We may receive a commission if you buy something using a link on this page.

Find out how this list was made

In order to help you find a good product, we’ve researched & compared the best probiotic supplements on the market right now.

10 Best Probiotic Products Compared

ⓘ If you buy something after visiting a link below, we get a commission.

1. Garden of Life Raw Probiotics

Garden Of Life Raw Probiotics

Garden of Life RAW Probiotic has the highest concentration and widest diversity of probiotic bacteria of all of the products on this list. This is also a superior-quality product, derived from wholefoods.


  • 100 billion cultures (CFUs) per serving
  • 34 probiotic strains
  • Derived from wholefoods

What’s in it: One serving contains:

  • 100 billion active probiotic cultures from 34 different strains.

Who makes it: RAW Probiotics are made by Garden of Life, the #1 brand in the natural products industry. All garden of life products is made from real wholefoods. Garden of Life aims to bring clean, traceable products to its customers, with no synthetic ingredients.

Bottom line: RAW Probiotics contain a massive amount of active bacteria per capsule and are derived entirely from wholefoods. Garden of Life also offers gender and age-specific formulations and contain high vitamin content.

Where to Get It

2. Renew Life Ultimate Flora Critical Extra Care

Renew Life Ultimate Flora Critical Extra Care

Ultimate Flora Extra Care is a powerful probiotic supplement made by Renew Life. With 50 billion live cultures in each enteric-coated capsule.


  • 50 billion cultures (CFU’s) per capsule
  • 10 different probiotic strains
  • Enteric-coated capsules to delay the release
  • Promotes digestive health
  • High culture count
  • Well received user reviews
  • Affordable
  • Excellent value for money
  • Quality guaranteed

What’s in it: One serving contains:

  • 50 billion active probiotic cultures from 10 different strains

Who makes it: Renew Life is a large supplement manufacturer with a focus on digestive health supplements. In fact, they currently only produce probiotics and other digestive aids. This focus allows them to create highly innovative and effective products while keeping prices low and quality high.

Bottom line: The huge culture count, combined with innovative coated capsules and the backing of a very reputable company, make these an easy choice for our list. Renew Life, the company behind these capsules, ONLY makes digestive aids – so you can rest assured that they know what they are doing.

Where to Get It

3. Dr. Mercola Complete Probiotics

Dr Mercola Complete Probiotics

Dr. Mercola Complete Probiotics is a strong probiotic supplement with 70 billion CFUs per serving. Packed with 10 different strains of healthy probiotics, Complete Probiotics is convenient and powerful.


  • 70 billion CFU’s per serving
  • 10 strains
  • Coated to resist stomach acid (increases digestion rate)
  • Stable at room temperature
  • 18-month shelf life
  • Good value for money
  • Well reviewed

What’s in it: One serving contains:

  • 70 billion active cultures (CFU) from 10 different strains

Who makes it: Complete Probiotics are made by Dr. Mercola Premium Supplements. Founded and run by Dr. Joseph Mercola, this company makes high-quality fitness and health supplements for a wide range of people. Dr. Mercola is a health expert, published author, and TV personality with the experience and resources to make high-quality products.

Bottom line: With a massive culture count of 70 billion, each serving packs quite a punch in terms of health benefits. Also, the fact that this product is shelf-stable with a 18+ month shelf life is a huge plus. The only downside is that it’s a bit more expensive than some of our other recommendations.

Where to Get It

4. NOW Foods Probiotic-10


NOW Foods Probiotic-10 is one of the best probiotics available. With 25 billion active cultures in each capsule, Probiotic-10 promotes healthy intestinal flora and improves many aspects of physical health.


  • 10 unique probiotic strains
  • 25 billion cultures (CFU’s) per capsule
  • Vegan
  • Dairy, wheat & gluten-free
  • Made by a great company
  • Excellent value for money
  • Great reviews
  • High culture count
  • Convenient single-capsule serving size

What’s in it: One serving contains:

  • 25 billion active cultures from 10 different strains

Who makes it: Probiotic-10 is made by NOW Foods, a large scale manufacturer of health foods and health supplements. From humble beginnings in 1948, NOW Foods has grown into one of the largest names in the business, currently producing more than 1,400 different dietary supplements and health foods. NOW has earned a reputation of quality and consistency in the health food community, making them one of our top recommended probiotic producers.

Bottom line: Overall, Probiotic 10 is a fantastic product and one of the strongest probiotic supplements available. We recommended it because of its high culture count, affordable price, and because it comes from a reputable and trustworthy company.

Where to Get It

5. Healthy Origins Probiotic

Healthy Origins Probiotic

Healthy Origins Probiotic is a good probiotic supplement with 30 billion colony forming units (CFU’s) per capsule. Formulated with 8 different probiotic strains, Healthy Origins Probiotic is designed for your digestive health. It’s also shelf-stable, which is certainly a notable benefit!


  • 30 billion CFU’s per serving
  • Coated capsules for delayed digestion
  • Shelf-stable – does not require refrigeration
  • Convenient 1 capsule serving size
  • Very affordable
  • Well reviewed

What’s in it: One serving contains:

  • 30 billion active cultures from 8 different strains

Who makes it: This product is made by Healthy Origins, a mid-sized supplement manufacturer founded in 1996. For the past 20 years, Healthy Origins has been committed to providing a healthy value from reliable origins – making highly effective and affordable products using natural ingredients.

Bottom line: Overall, Healthy Origins Probiotic is a great natural probiotic. It’s easy to take, with only 1 capsule needed, it’s highly affordable, and it’s shelf-stable, meaning there’s no need to refrigerate it. Lastly, we recommend this product because Healthy Origins is a well-known company who consistently produces high-quality products.

Where to Get It

6. Puritan’s Pride Premium Probiotic 10

Puritans Pride Premium Probiotic 10

Puritan’s Pride Probiotic 10 is a rapid-release probiotic supplement containing 20 billion live cultures per serving. With an advanced formula that uses 10 different probiotic strains, this product is well-balanced and effective.


  • 20 billion CFUs per serving
  • 10 different strains
  • Rapid release formula gets to work fast
  • Affordable

What’s in it: One serving contains:

  • 20 billion active cultures (CFUs) from 10 different strains

Who makes it: Probiotic 10 is made by Puritan’s Pride, a large scale producer of supplements and other health products. For more than 40 years, Puritan Pride has worked hard to develop cutting-edge products to meet the needs of their customers. Based in Long Island, NY, Puritan’s Pride now has customers worldwide.

Bottom line: Overall, Puritan’s Pride Probiotic 10 is a good probiotic. It offers 20 billion CFUs per serving, which is lower than average but still very beneficial. It’s made by a very well reputed company, and it comes at a very reasonable price, making it an easy choice for our list of recommendations.

Where to Get It

7. Nutrition Now PB8

Nutrition Now Pb8

Nutrition Now PB8 is an affordable and effective probiotic supplement. With 14 billion CFUs per serving, it’s on the lower end in terms of culture count, but it’s very affordable – and you can always take more than 2 servings a day to increase your probiotic intake.


  • 14 billion CFUs per serving
  • 8 different strains
  • Very affordable
  • Well reviewed

What’s in it: One serving contains:

  • 14 billion active cultures (CFUs) from 8 different strains

Who makes it: Nutrition Now PB8 is made by Nutrition Now, a manufacturer of health supplements. Founded in 1998, Nutrition Now has kept operations small while focusing on quality over quantity approach. Today, they have developed a loyal following of fans who love their vitamins and health supplements.

Bottom line: Overall, Nutrition Now PB8 is a good product from a good company. It’s got a lower probiotic content than most products on this list, but it uses high-quality ingredients. It’s also quite affordable, which is great for those on a budget.

Where to Get It

8. Culturelle Digestive Health Probiotic

Culturelle Digestive Health Probiotic

Culturelle Digestive Health Probiotic is an effective probiotic supplement with 10 billion active cultures per serving. This once-per-day supplement provides your body with a solid dose of healthy bacteria that can help to keep your digestive system on track, while supporting immune health and more.


  • 10 billion CFUs per serving
  • 1 probiotic strain
  • One capsule per day

What’s in it: One serving contains:

  • 10 billion active cultures (CFUs) from 1 different strain

Who makes it: This product is made by Culturelle, a large scale probiotic supplement manufacturer. For many years, Culturelle has specialized in digestive health supplements like probiotics. They use a unique strain of probiotic known as Lactobacillus GG, a clinically proven strain that serves as their main active ingredient.

Bottom line: Overall, Culturelle Digestive Health Probiotic is a good option for some. It’s got a lower culture count than average, and unlike most products on this list, and it also only uses a single strain of probiotics. Research has shown that probiotic mixtures appear to be more effective than single-strain products, so keep that in mind.

Where to Get It

9. Jarrow Formulas – Jarro-Dophilus EPS

Jarrow Formulas Jarro Dophilus Eps

Jarro-Dophilus EPS contains 5 billion active bacteria that are stable at room temperature per capsule. These probiotics don’t need to be refrigerated. They also come encased in an EnteroGuard coating, to help ensure that they reach the gut alive, ready to work their magic.


  • 5 billion cultures (CFUs) per capsule
  • 8 complementary strains of bacteria
  • Stable at room temperature
  • EnteroGuard coating to protect against stomach acid

What’s in it: One serving contains:

  • 5 billion active probiotic cultures from 8 different strains.

Who makes it: Jarro-Dophilus EPS is made by Jarrow Formulas, a California-based nutritional supplement brand. With over 30 years’ experience in the field, Jarrow Formulas has a great reputation for superior-quality products and excellent customer service.

Bottom line: Jarro-Dophilus EPS doesn’t contain the tens of billions of active cultures that some other probiotic brands offer. However, high number of cultures aren’t necessary when you don’t have to worry about losing them to heat or stomach acid. The tablets are designed to ensure that as much of the active ingredients as possible make it to your intestine, making them a highly effective choice.

Where to Get It

10. Bio-Kult Probiotic

Bio Kult Probiotic

Bio-Kult Probiotic is an advanced multi-strain probiotic formula. Made by Bio-Kult, this product is shelf-stable and contains probiotics from 14 different strains. It contains 2 billion live cultures per capsule, which is on the low side.


  • 2 billion CFUs per capsule
  • 14 different probiotic strains
  • Lactic acid-based probiotic
  • Shelf-stable (so no need to refrigerate)

What’s in it: One serving contains:

  • 2 billion active cultures (CFUs) from 14 different strains

Who makes it: This product is made by Bio-Kult, a division of Probiotics International. For the last 20+ years, Probiotics International has been solely dedicated to developing innovative new digestive supplements using bacterial cultures. Today, they are fully accredited and have happy customers from all around the world.

Bottom line: Overall, Bio-Kult Probiotic is a good option for some. It contains 14 different probiotic strains, which is useful for those who would like to diversify their sources of these helpful bacteria. On the other hand, the culture count in these capsules is fairly low, so it’s a bit expensive for what it is.

Where to Buy

Frequently Asked Questions About Probiotics

What Are Probiotics?

There are many types of bacteria present both inside our bodies and in our environments.

Some are bad, causing disease, infection and worse. And some are good, helping the body to regulate digestive health, improve immune function, and more.

These “good bacterias” are often referred to as probiotics.

You probably know the word antibiotic (a medicine designed to destroy infection and bacteria), but you may be less familiar with probiotics.

Probiotics are live bacteria and/or yeasts that are considered good for your overall health.

These microorganisms are naturally found in the human body, as well as in certain foods and supplements.

In foods, the most common probiotic-containing ingredients are fermented or cultured ones.

Yogurt, sauerkraut, kefir, kombucha, etc. all contain powerful probiotics, which are created naturally through the fermentation process.

Other foods contain probiotics that are added in on purpose, to help you increase your daily intake of these helpful gut bacterias.

Then, finally, we have probiotic supplements.

Generally found in capsule form, probiotic supplements will deliver a concentrated dose of live cultures and bacterias, which can help regulate digestive health and promote many aspects of wellbeing.

What Are the Benefits of Probiotics?

Probiotics are a category of live bacteria and yeast that may have beneficial health effects. They are particularly helpful for the digestive system.

Probiotics are found naturally in yogurt and fermented foods and can also be taken in pill form.

Some common uses for probiotics include:

  • Balance of Gut Bacteria: Probiotics can help to restore the natural balance of gut bacteria (1). We all have bacteria in our digestive systems, some good bacteria, and some bad. And imbalance occurs when there is too much “bad” bacteria, and not enough beneficial bacteria. Probiotic supplements can help boost levels of beneficial live microorganisms (2), helping to restore the balance of gut bacteria.
  • Diarrhea: Probiotics may help reduce symptoms of diarrhea, particularly when it comes to antibiotic-induced diarrhea (3). Many people experience diarrhea after taking antibiotics, since antibiotics can negatively affect the balance of bacteria in the gut (4). In patients experiencing antibiotic-induced diarrhea, one study found that probiotics reduced the symptoms by 42% (5). Probiotics may also be effective in reducing diarrhea caused by other conditions, including infectious diarrhea (6), traveler’s diarrhea (7), and others.
  • Mental Health: Several studies have outlined a clear link between gut health and mental health (8). Researchers are still working to fully understand the mechanisms, but both animal and human studies have shown that probiotic supplements can help improve symptoms of certain mental health conditions (9). The probiotic strains Bifidobacterium and Lactobacillus appear to be particularly effective, with a meta-review of 15 human trials (10) finding a notable improvement in anxiety, depression, OCD, and other mental health concerns.
  • Heart Health: Certain strains of probiotics may help to improve heart health. Some strains help to break down bile in the gut (11), which reduces the amount of cholesterol entering the bloodstream. A review of studies observed that eating probiotic-containing yogurt for 2-8 weeks resulted in a reduction of total cholesterol by 4% (12). With that said, other studies have found no effect, so more research is needed.
  • Digestive Disorders: Certain digestive disorders, such as irritable bowel syndrome (IBS) and ulcerative colitis, may be improved by taking probiotics (13). Preliminary research shows certain strains have significant promise in countering IBS symptoms (14), although more research is needed.
  • Immune Health: Taking probiotics may help to improve the health of your immune system. By inhibiting the growth of harmful gut bacteria (15) and improving the production of natural antibodies (16), certain probiotics can improve immune health from both sides. Different strains have different effects (or none at all), so more research is needed.
  • Weight Management: While they are definitely not the best fat burning pills, some evidence suggests that probiotics may help with weight management in some individuals. Several mechanisms contribute to this effect. For one, some probiotics help to block the absorption of dietary fat (17) in the digestive system. A healthy gut may also contribute to a higher calorie burn rate (18). However, different strains have vastly different effects, with certain strains actually contributing to weight gain (19) in some individuals. More research is needed.

Who May Benefit From Probiotics?

If you’re wondering what type of people can benefit from taking probiotics, here’s your answer:

  • People with digestive issues – The people who can benefit most from probiotics are those with digestive issues, such as irritable bowel syndrome, diarrhea, inflammatory bowel disease, and other digestive disorders and conditions. These folks can greatly benefit from the helpful gut flora that comes in each probiotic capsule, as these bacteria help to regulate the digestive system and restore the body’s natural ability to properly digest and process foods.
  • Anyone who has taken antibiotics recently – If you’ve recently taken a course of antibiotics, regardless of your reasoning for doing so, it’s a great idea to add a probiotic to your diet. Why? Well, antibiotics kill gut bacteria. They are designed to get rid of the bad bacteria that is causing your health issue, but unfortunately, they also destroy the good bacteria that your body needs to function properly. Adding a probiotic to your diet can replace that gut flora to restore a normal digestive system.
  • Vegans – Probiotics are found naturally in certain foods, but the best food sources are mostly dairy products, like yogurt and kefir. For vegans and others who avoid dairy, it can be difficult to get enough good bacteria in your natural diet – although there are some vegan food sources of probiotics. Vegan friendly supplements can help up your natural intake and improve digestive health.
  • Men and women of all ages – Long story short, just about anyone can benefit from these products. There are generally no gender-specific ingredients found in these products, so the best probiotics for men are generally the same as they are for women. Even if you consider yourself to be a healthy individual, you may still benefit from taking a good supplement to improve your gut flora.

How Do I take Probiotics?

These supplements are generally found in pill or capsule form. They are pretty affordable and readily available at both online retailers and supplement stores.

Each product will have slightly different dosages and usage instructions, so pay attention to the bottle of your specific supplement.

In general, it’s best to take probiotics with other food in your stomach.

Sometimes, if you take a pill on an empty stomach, you may experience some minor discomfort. So, it’s a good idea to take them with a meal.

As with any supplement, it’s important to follow the instructions on the product packaging. Take the recommended dose and follow the instructions – do not take more than recommended unless you talk to your doctor first!

Also, of note – you should take care when storing probiotic supplements.

These capsules contain live cultures, bacterias, and microorganisms.

Since they are actually alive, they are sensitive to increases in temperature and other improper storage techniques.

Depending on the product and how it is made, your supplement may or may not recommend refrigeration. Read the product packaging to determine whether or not you need to refrigerate your capsules.

Even if it doesn’t require refrigeration, you should take care to keep your capsules out of direct sunlight and avoid rapid increases in temperature (so don’t keep the bottle next to your oven!)

This is another reason that you should buy probiotics from good sources. As these products age, they slowly lose potency. So, don’t buy from discount websites or unknown sources.

Try to buy only high-quality products from reputable companies. Hint: we’ve done some work for you with our above list.

How long does it take for probiotics to work?

That really depends on what you’re using them for.

Generally, they get to work pretty quickly, and you should see results within a week, but again, it really depends what you’re using them for.

Are There Any Side Effects of Probiotics?

Whether you’re taking probiotics for constipation, digestive issues, to boost your immune system, or for another reason, you should be aware of potential side effects.

Generally, you won’t experience any side effects from taking probiotic supplements, so long as you follow the instructions and don’t take too much.

However, with that being said, there are a few potential side effects of probiotics to be aware of:

  • Stomach discomfort/gas

Some people may experience minor stomach discomfort, gassiness, or bloating after taking probiotics.

This is fairly rare, but it does happen.

For some, it’s useful to take these supplements on a full stomach to avoid this potential side effect.

Also – generally speaking, those with weakened immune systems, such as those with chronic diseases, are more likely to experience gas from these supplements.

  • Allergic reactions

Very rarely, people experience allergic reactions to ingredients found in probiotics. It’s rare, but it does happen – although, the same could be said for just about every supplement and food product out there!

Note: Consult your doctor before taking any supplements.

How Do I Pick a Good Probiotic Product?

Because there are many different types of these supplements from many different companies, it can often be hard to pick the best one for you.

Let’s go over what you should look for when choosing a supplement:

  • Probiotic content – First and foremost, take a look at the actual count of probiotic cultures (measured in CFUs or colony forming units) in each capsule. Generally, it will be a HUGE number, like 10 or 50 billion. This number is useful for comparing two different products, but it doesn’t tell you everything you need to know.
  • Types of probiotics – As stated, there are many different types of beneficial bacterias. Lactobacillus and bifidobacterium are the two most common, although there are different strains within each of those categories. If your doctor has told you to take a specific culture, look closely at the ingredient labels.
  • Brand quality – There are a ton of companies who make these supplements, and they’re not all created equal! The most trustworthy probiotic brands will use high-quality ingredients, thorough quality control and rigorous testing to produce the highest quality product possible. Lower quality brands cut corners and end up delivering lower-quality products. Read user reviews to find the best brands, or check our list of recommendations above.
  • Value – Price should not be the main deciding factor, but it’s always going to be a factor (unless you’re rich!) Keep an eye on the per-serving or per-day price of each product you’re comparing. You don’t necessarily want cheap probiotics, though, so look for a quality option at a reasonable price.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

Share this post:

About the Author