Minerals Berberine

Best Berberine Supplements – Top 10 Brands for 2022

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Find out how this list was made

In order to help you find a good product, we’ve researched & narrowed down the best berberine supplements on the market right now.

Top 10 Berberine Products Compared

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1. Sunergetic Premium Berberine Supplement

Sunergetic Premium Berberine Supplement

Sunergetic Premium Berberine Supplement is made using the highest quality berberine HCL extract in a quality dosage. This product is manufactured in an FDA-registered GMP certified facility in the United States.


  • 1200mg berberine HCL
  • Made in the USA
  • FDA-registered GMP certified facility
  • Uses berberine HCL

Who Makes It?

Sunergetic is a premium natural supplement brand that was founded in 2012 and believes in the healing powers of nature. Their products are all manufactured in GMP certified facilities with the utmost attention to quality. They have so much faith in their products that they even offer a 365-day money-back guarantee if you are unsatisfied.

Bottom Line: This product is manufactured by a reliable company with the best quality ingredients – and it provides you with a pure source berberine.

Where to Get It

2. Thorne Research – Berberine


Thorne Research Berberine is a berberine HCL pill that is manufactured using vegetarian capsules. It is free from dairy, eggs, nut-based ingredients, gluten, artificial preservatives, high-fructose corn syrup, and stearates.


  • 1000mg berberine HCL
  • Berberine HCL pill
  • Vegetarian capsules
  • Free from dairy, eggs, nut-based ingredients, gluten, and high-fructose corn syrup
  • Free from artificial preservatives and stearates

Who Makes It?

Thorne Research is a nutritional supplement brand that has been supplying consumers with top quality nutritional supplements for over 30 years. Their manufacturing facilities are distinguished with certifications such as the NSF International Certification, TGA Certification, and the FDA’s GMP certification. They offer a variety of products including cardiovascular, liver, endocrine, immune, gastrointestinal, neurological and metabolic supports.

Where to Get It

3. Dr. Whitaker’s Berberine

Dr Whitakers Berberine

Dr. Whitaker’s Berberine is developed by the pioneer of alternative medicine, Dr. Julian Whitaker, it is designed to be taken once with every meal for a total daily berberine supplement dosage of 1,500mg.


  • 500mg BerberPure Berberine HCL
  • Made in the USA
  • Gluten-free
  • Formulated by Dr. Julian Whitaker
  • Clinical grade berberine

Who Makes It?

Dr. Whitaker is a pioneer in the alternative medicine field. He has spent more than 40 years helping people improve their health with safe, natural supplements, and he has also founded the Whitaker Wellness Institute. He was educated at Dartmouth College and achieved his MD at Emory University. His health philosophy is preventative rather than curative.

Bottom Line: This product does contain more binders than some alternative ones.

Where to Get It

4. We Like Vitamins Berberine

We Like Vitamins Berberine

We Like Vitamins Berberine is an affordable berberine HCL pill that is made in the USA in a GMP certified facility. It does not include artificial colors, flavors or preservatives; and it is free from yeast, corn, milk, milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.


  • 900mg berberine HCL
  • Affordable
  • Made in the USA
  • Manufactured in a GMP certified facility
  • Free from artificial colors, flavors or preservatives
  • Free from yeast, corn, milk, salt, sodium, soy, sugar, gluten, starch or wheat

Who Makes It?

We Like Vitamins is a newer supplement brand that produces 24 different vitamins, herbal and amino acid products. Their products are all backed by their 100% money-back guarantee.

Where to Get It

5. Vitamins Because Pure and High Potency Berberine

Vitamins Because Pure And High Potency Berberine

Vitamins Because Pure and High Potency Berberine is a berberine HCL pill encapsulated in gelatin for quick release. It is an affordable and effective berberine supplement that is free from artificial flavoring, coloring, preservatives, yeast, corn, milk, lactose, sodium, salt, sugar, soy, gluten, starch or wheat.


  • 900mg berberine HCL
  • Affordable
  • Uses berberine HCL
  • Free from artificial flavoring, coloring, and preservatives
  • Free from corn, milk, sugar, salt, soy, yeast, gluten, starch and wheat
  • Anti-inflammatory


  • Uses rice powder filler
  • Less effective than some alternatives
  • Lesser reputable brand

Who Makes It? Vitamins Because is a manufacturer of 1300 different vitamin products that has been in the industry for over 50 years. The company was founded in Florida. They only produce supplements in capsule forms, and they do not use chemicals or preservatives. Instead as a filler, they use rice flour.

Where to Get It

6. Swanson Berberine

Swanson Berberine


  • 400mg berberine HCL
  • Affordable
  • Uses berberine HCL
  • Manufactured in a GMP certified facility

Who Makes It?

Swanson Vitamins is a supplement brand that produces a large variety of dietary supplements at affordable prices. They were founded in 1969 by Leland Swanson, a golfer who was searching for natural remedies for his developing arthritis. Today, Swanson sells health products for the heart, immune system, joints, probiotics, memory and brain support, vision support, anti-aging, and even beauty products.

Bottom Line: This is one of the most effective berberine supplements on the market that comes at an affordable price. It provides you with all of the berberine benefits in a single pill, making it easy to add to your daily regimen.

Where to Get It

7. Bulksupplements Pure Berberine HCL Powder

Bulksupplements Pure Berberine HCL Powder

This is pure berberine HCL powder that is lab tested for guaranteed purity, and it can be purchased in bulk. Due to its powdered form, dosing can be customized to your needs. It is free from sugar, soy, dairy, yeast, gluten, corn or additives.


  • 500mg berberine HCL
  • Affordable
  • Berberine HCL powder
  • Free from sugar, soy, dairy, yeast, gluten, corn and additives
  • Customizable berberine supplement dosage

Who Makes It?

Bulksupplements is a supplement ingredient supplier that manufactures over 200 pure nutritional ingredients in an FDA-registered GMP certified facility. They offer products in amounts from grams to metric tons to both supplement companies and individual consumers! All of their supplements are tested for purity and quality control before leaving their facility, which guarantees that their products are safe.

Bottom Line: You have total control of your berberine dosage with this powder. There are no additional ingredients, and you can customize the dosage to your needs. This is why Bulksupplements Pure Berberine HCL Powder is one of our picks.

Where to Get It

8. Amazing Nutrition Amazing Formulas Berberine Plus

Amazing Nutrition Amazing Formulas Berberine Plus

Amazing Nutrition Amazing Formulas Berberine Plus is a berberine HCL pill that is intended to be taken with every meal. It is made in a GMP certified facility in the USA and has been 3rd party tested to ensure quality.


  • 500mg berberine HCL
  • Made in the USA
  • GMP certified manufacturing facility
  • 3rd party tested
  • Berberine HCL pill

Who Makes It?

Amazing Nutrition is a supplement producer that offers vitamins, herbs, omega fats, whole foods, and sports nutrition supplements. All of their products are manufactured in the USA at their GMP certified facilities. The company is based out of Jersey City, New Jersey.

Bottom Line: Amazing Nutrition Amazing Formulas Berberine Plus is a good choice, however it uses a large ratio of rice flour in the product as a filler. It is also a bit pricier than some alternatives.

Where to Get It

9. Integrative Therapeutics – Berberine Complex

Integrative Therapeutics Berberine Complex

Integrative Therapeutics – Berberine Complex is a berberine formula that includes goldenseal and Oregon grape extracts. Goldenseal and Oregon grape both naturally contain berberine, and can contribute additional compounds to this complex.


  • 400mg barberry root extract
  • 400 ng Oregon grape extract
  • Includes traditional herbs goldenseal and Oregon grape

Who Makes It?

Integrative Therapeutics is a health supplement brand that combines the wisdom of traditional, naturopathic and alternative medicines with conventional medicine to produce well-rounded and effective health products. The brand was created through a collaboration with Vitaline Formulas, NF Formulas, Tyler Encapsulations, Phytopharmica, and Schwabe.

Bottom Line: If you are looking for a natural, herbal remedy, this may be the right berberine supplement for you. It also includes additional antioxidants from the variety of berberine herbs used in this formula, making it a good anti-aging supplement. However, it is more expensive and it does not use berberine HCL.

Where to Get It

10. Solaray Berberine Special Formula

Solaray Berberine Special Formula

Solaray Berberine Advanced Formula is formulated with Oregon grape extract. The only other ingredients in this product is the vegetarian capsule it comes in, which means it is free from fillers!


  • 250mg berberine HCL
  • 285mg Oregon grape extract
  • Includes Oregon grape extract
  • Uses berberine HCL
  • Vegetarian capsule

Who Makes It?

Solaray is a well-known nutraceutical manufacturer that was founded in 1973 in Utah, and acquired in 1993. The company has been a pioneer in the herbal supplement industry, offering more than 1,000 herbal products.

Bottom Line: This is a good choice of berberine which also provides additional antioxidant benefits of Oregon grape extract. However, it is more of an Oregon grape supplement than a berberine pill – it has a lower dosage of berberine than Oregon grape. The combined doses are low as well.

Where to Get It

Frequently Asked Questions About Berberine Supplements

What is Berberine?

Berberine is a compound that is found in many good natural sources, and it is one of the most studied natural supplements available.

One of its most notable sources is the root of a plant called barberry, which is a shrub of different varieties that produce flowers. Berberine powder is bright yellow, similar to turmeric or curcumin.

It has been used medicinally for over 2,500 years, by ancient and modern cultures. Today, berberine supplements come in the forms of capsules, tablets, extracts and more.

What Are the Uses & Benefits of Berberine?

Berberine is most well known for its anti-inflammatory properties. It activates an enzyme inside cells called AMP-activated protein kinase (AMPK) that is often called a “master switch” due to its regulatory effects on body fat composition and lifespan. When activated, this enzyme stimulates metabolic function.

It is a natural alkaloid that’s found in a wide variety of herbs. In supplement form, the alkaloid has been found to have a number of pharmacological effects, which may offer benefits including:

  • Diabetes: Berberine has shown some promise as a potential natural remedy for diabetes. In one study, the use of berberine supplements was found to lower levels of blood glucose, an effect which may help to treat existing type II diabetes, and potentially even reduce the risk of developing the disease in the first place. Another study found that berberine was equally as effective as metformin, a popular diabetes drug, at controlling type II diabetes symptoms. Berberine may also improve insulin sensitivity, which not only helps control diabetes but may also reduce the risk of kidney damage. More research is required, but the ongoing management of diabetes is where berberine shows the most promise.
  • Cholesterol: Berberine may help to lower high cholesterol levels, particularly in those with diabetes. One study found that berberine combined with red yeast rice provided a broader range of cholesterol protection – along with the lower risk of adverse side effects – when compared to statin therapy, a common cholesterol treatment. Animal studies have also found berberine to be effective in reducing abnormally high fat and lipid concentrations in the blood by helping the liver to excrete cholesterol. More research is needed, but preliminary evidence shows promise.
  • Obesity: Berberine has been the focus of some studies seeking alternative options to fight obesity. Clinical evidence is limited at this time, but one study found it effective in lowering lipid levels and observed that berberine could have a moderate weight loss effect in obese participants. More research is needed.
  • Alzheimer’s Disease: Berberine may show some promise in fighting neurodegenerative diseases including Parkinson’s and Alzheimer’s. One study found that berberine had the potential to enhance neuroprotective pathways, leading researchers to believe that it may be beneficial in reducing the risk of neurodegenerative diseases. While preliminary results show promise, much more research is needed.
  • Hearth health: Since berberine has shown promise in keeping obesity and blood sugar levels in check, researchers believe it may also be beneficial in protecting heart health. Berberine is thought to increase the release of nitric oxide in the body, which helps relax arteries and allow for better blood flow and lower blood pressure. One study found berberine had positive effects on heart health and may be beneficial in addressing heart failure and heart arrhythmias. More research is needed.

Berberine is a supplement that shows a lot of promise in a number of areas, although many aspects of its effects require significantly more research.

Who Can Benefit from Berberine?

  • Those who are Overweight – Berberine’s metabolic benefits can help to improve weight loss efforts in conjunction with exercise and a healthy diet. By activating the “master switch” enzyme AMPK, it stimulates the metabolism and improves one’s ability to burn energy from foods – rather than store it in fat cells. This process also helps to enhance energy levels, because more of the food you eat is used as energy! If you are dieting, this is essential, because your body won’t be used to the cut in calorie intake.
  • Those with Cardiovascular Health Issues – The cardiovascular system includes veins, arteries, and the heart. This important system pumps nutrients and oxygen throughout the body via your blood. Many different issues can afflict this system, including high blood pressure, high cholesterol levels, high blood sugar levels and more. All of these factors increase the risk of heart disease.
  • Those with Digestive Issues – Your digestive health and function can be affected by factors such as inflammation and bacteria growth in the gut. Excess inflammation in the digestive system can be caused by the immune system attacking bacterial overgrowth in the gut, making these issues go hand-in-hand. Sometimes inflammation can a type of Inflammatory Bowel Disease (IBD). Berberine can help to balance the bacteria in your gut by killing bacteria that are bad, such as candida yeast. It can also help support the immune system and reduce the inflammatory response, making it a good supplement for digestive health.
  • Athletes – Athletes looking to cut weight and improve their body composition can benefit from taking a berberine supplement. Due to berberine’s beneficial effects on weight loss, it can help athletes reach a lower body fat composition. Simultaneously, it can also enhance energy levels to improve athletic performance.

Are There Any Side Effects of Berberine?

Berberine usually does not cause negative side effects, and it is generally well-tolerated. However, high doses of berberine may cause side effects such as diarrhea and stomach cramps. Berberine can interact negatively with antibiotics as well, so do not take berberine in conjunction with antibiotics.

How Do I Take Berberine?

Due to berberine’s metabolic benefits, it is best taken with a meal. For berberine supplement dosage instructions, follow the directions on your particular supplement.

Not enough research has been conducted on the effects of berberine on children, so consumption by children is not recommended.

Are There Any Beneficial Berberine Stacks?

Berberine can also be stacked with some other supplements to become even more effective for your needs. The more effective berberine stacks have synergistic benefits, which means that each supplement is more beneficial together than they are separately.

Here are a few good berberine stacks:

  • Berberine and Quercetin – For inflammation and supporting the immune system, quercetin and berberine make a good stack. Quercetin is a plant pigment with powerful antioxidant properties that has anti-inflammatory and antihistamine benefits. It also is cardioprotective, which makes it a good compliment to berberine.
  • Berberine and Milk Thistle – Milk thistle is an herbal remedy that has been used for over 2,000 years to protect the liver from toxins and inflammation. Milk thistle and berberine make a powerful berberine stack for supporting the immune system and digestive health, as well as detoxifying and alkalizing the body.
  • Berberine and Oregon Grape and/or Goldenseal – Goldenseal and Oregon grape both naturally contain berberine, and combining them adds additional antioxidant varieties. It also helps to reinforce berberine benefits for the digestive system and cardiovascular system.

How Do I Pick a Good Berberine Product?

A high-quality berberine supplement should be made using berberine HCL because it is the most widely studied form available, and has been found to be the most easily absorbed.

Berberine pills and powders also should be bright yellow and free from artificial colors – this way you can see that there is actually quality berberine in the product.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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