Amino Acids Betaine

Best Betaine Supplements – Top 10 Brands for 2022

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Your body works very hard to keep you healthy.

You may not ever think about it, but it is working hard every second of the day to maintain your cells, tissues, and organs.

This requires energy, nutrients, and lots of biochemical reactions. Your body produces so many reactions that within 30 minutes, you will have released enough heat to boil a gallon of water.

Doesn’t that sound tiring?

It turns out that it is. Aging proves that. As you get older and continue to wear down your cells through energy production, consumption, and biochemical reactions that keep the process going.

This results in reduced levels of certain compounds that facilitate these reactions because they are constantly being used. One of these compounds is an amino acid called betaine, which supports the health of your body throughout your life.

As you age, the levels of betaine in your body decrease, which leaves you more vulnerable to cellular damage, toxification, and certain health conditions. Luckily, betaine comes in supplemental form for those who are deficient and those interested in its anti-aging effects.

Top 10 Betaine Products Compared

In order to help you find a good product, we’ve researched & narrowed down the best betaine supplements on the market right now.

ⓘ If you buy something after visiting a link below, we get a commission.

1. Transparent Labs RawSeries Betaine


Transparent Labs RawSeries Betaine is a raw betaine anhydrous supplement that comes in a powdered form. It can be taken with or without a meal, and it provides all of the best benefits of betaine without any fillers.


  • Betaine anhydrous powder
  • No fillers are added ingredients
  • Affordable

What’s in it:

  • 5g betaine anhydrous

Who makes it: Transparent Labs is a well known dietary supplement producer that strives for quality and integrity with every product. They are 100% transparent when it comes to their products, and you can trust that they are telling you everything that is in their supplements. They absolutely never use artificial sweeteners, food dyes, or harmful additives, and their RawSeries products are some of the purest products on the market.

Bottom line: TLabs offers pure betaine anhydrous in a powdered form that is easily stacked (with TLabs premium BCAA supplement, for example) and allows for a customizable betaine dosage. This high-quality supplement provides a large quantity of high-quality betaine for an affordable price.

Where to Get It

2. Nutricost Betaine Anhydrous Trimethylglycine


Nutricost Betaine Anhydrous Trimethylglycine is a betaine powder that is made in the USA and is intended for use as a dietary supplement or an athletic support supplement. It’s powdered form allows you to customize your betaine dosage which is preferable for athletes who may want to experiment with different dosages and stack ratios. It provides a massive quantity of betaine, with 333 servings of 1.5 grams in one container,  which is great for those who would be taking this supplement frequently.


  • Gluten-free
  • Made in the USA
  • Huge quantity
  • Affordable

What’s in it:

  • 5g betaine anhydrous

Who makes it: Nutricost is a dietary supplement producer that supplies products such as amino acids, vitamins, protein, and both general health and workout supplements. Their products come backed with a 100% money-back guarantee because they have that much confidence in their formulas. They claim to produce the purest forms of individual ingredients.

Bottom line: This is a great betaine supplement if you need a large quantity at an affordable price because in one container you get 333 servings. This number may be more if you choose to use a lower dose than the supplement facts recommend. However, this product does have additional ingredients of silicon dioxide and calcium silicate.

Where to Get It

3. Country Life Betaine Hydrochloride

Country Life Betaine Hydrochloride

Country Life Betaine Hydrochloride comes in tablet form and includes supporting enzymes pepsin, papain, and bromelain.


  • Includes supporting enzymes pepsin, papain, and bromelain
  • Affordable

What’s in it:

  • 1200mg betaine HCl
  • 4mg pepsin
  • 10mg papain
  • 10mg bromelain

Who makes it: Country Life is a health and wellness supplement producer that has been in the health foods industry for over 40 years. Since 1971, they have been passionate about providing customers with quality and purity in their products. They mainly produce vitamins, supplemental tablets, and gummies, and they also produce health products for children.

Where to Get It

4. Thorne Research – Betaine HCL

Thorne Research Betaine Hcl

Thorne Research – Betaine HCl is intended as a digestive support supplement and offers betaine HCl and the enzyme pepsin in capsule form. It is entirely free from GMOs, soy, dairy, egg, peanuts, yeast, magnesium stearate, binders, coatings, artificial colors, flavors, or sweeteners.


  • Does not include many allergens
  • No GMOs
  • Includes pepsin to enhance digestion

What’s in it:

  • 1g betaine HCl
  • 47mg pepsin

Who makes it: Thorne Research is a dietary supplement manufacturer that was first established in 1984 when they released their first product, ascorbic acid. It was founded in Seattle, Washington with the vision of helping others improve their health all around the world. They are now an internationally known dietary supplement brand that has been involved in research and programs to expand our health knowledge.

Where to Get It

5. Now Foods Betaine HCl


NOW Foods Betaine HCl is a betaine HCl supplement that comes in the form of a capsule. It also stacks betaine with the enzyme pepsin.


  • Affordable
  • Quality betaine dosage
  • Stacked with digestive enzyme pepsin

What’s in it:

  • 648mg betaine HCL
  • 150mg pepsin enzyme

Who makes it: NOW Foods is a natural supplement producer that manufactures top-quality all-natural dietary supplements. They have been in the industry since 1968 and are one of the well-respected brands amongst consumers and other producers. They are committed to sustainability, transparency, and promoting healthy living. They are considered one of the pioneers of the health foods industry.

Bottom line: This betaine pill is manufactured by a very reliable company that has been in the natural supplements industry since 1968. If you are looking for a good product with effective betaine dosage, this may be the product for you.

Where to Get It

6. BulkSupplements Pure Betaine Anhydrous


BulkSupplements Pure Betaine Anhydrous is a betaine powder that is free of sugar, soy, dairy, yeast, gluten, or any other additives. This is one of the better bulk betaine powders on the market and allows you the ability to customize your betaine dosage.

It functions as a great workout supplement and can be used as a convenient pre-workout supplement, intra-workout, or post-workout supplement depending on your needs. You can stack this supplement easily and it comes in a large quantity for a very affordable price.


  • Large quantity
  • Pure betaine anhydrous
  • Customizable betaine dosage

What’s in it:

  • 1500mg betaine anhydrous

Who makes it: BulkSupplements is a bulk supplement ingredient distributor that offers pure supplement ingredients to both consumers and producers. They are essentially a supplement wholesaler. They are located in Henderson, Nevada, and they supply over 200 different pure nutritional supplement ingredients in bulk at great prices. Their facilities are GMP certified, and they are also registered with the FDA.

Bottom line: BulkSupplements Betaine Anhydrous is a bulk powder that comes in a large quantity at a very affordable price. This is a great choice for serious athletes looking to redeem the benefits of betaine.

Where to Get It

7. Doctor’s Best Betaine HCI


Doctor’s Best Betaine HCl provides an effective dose of 650mg betaine HCl per betaine pill at a worthy price.


  • Affordable
  • Utilizes pepsin enzyme and gentian root

What’s in it:

  • 650mg betaine anhydrous
  • 25mg pepsin
  • 20mg gentian

Who makes it: Doctor’s Best is a dietary supplement brand that was founded by a physician in 1990 with the goal of helping others to improve their health. They offer more than 200 different products and use mostly branded ingredients that have been researched and tested for quality and efficacy. Their manufacturing facilities are all GMP certified, and they are committed to transparency with their products through education and communication.

Bottom line: This is a good betaine product for those who are looking for added digestive support ingredients. It offers a dose of betaine at an affordable price from a reliable manufacturer.

Where to Get It

8. Source Naturals – Betaine HCl


Source Naturals – Betaine HCl is a betaine HCl and pepsin supplement that can be taken with a large meal to enhance digestion and absorption. Overall, it is a good betaine supplement.


  • Includes pepsin

What’s in it:

  • 650mg betaine HCl
  • 165mg pepsin

Who makes it: Source Naturals is a natural supplement producer that specializes in vitamins and herbals. They are self-proclaimed leaders of the wellness revolution. Created in 1982 by Ira Goldberg with the idea of creating products that maintain well being and enhance life, they now are one of the biggest companies in the industry. They actually pioneered the idea of combining nutraceuticals, herbs, and many different nutrients into one supplement, which is a common practice today.

Bottom line: This product can be purchased at a reasonable price and is made by a reliable company. It is a great choice for someone who has never tried betaine HCl before and wants to test the waters. However, it does come in a low quantity and it uses more fillers than some other alternatives. It may not be the best choice for someone who knows that they will be using a lot of betaine.

Where to Get It

9. Biotics Research Betaine


Biotics Research Betaine is a betaine HCl supplement that is supported by the enzyme pepsin.


  • Betaine HCl supplement
  • Gluten and dairy-free

What’s in it:

  • 700mg betaine HCl
  • 10mg pepsin

Who makes it: Biotics Research Corporation is a nutritional supplement brand that is committing to using the best of science and nature to create nutritional supplements that are superior in quality and efficacy. They have been a leader in the industry for over 30 years and they have stuck to their mission the entire time. They strive to maintain excellence in nutritional science and produce high-quality and accessible health products.

Bottom line: Biotics Research Betaine includes HCl and pepsin, which are beneficial digestive aids. It provides all the betaine benefits you could ask for and it is manufactured by a reliable producer.

Where to Get It

10. Pure Encapsulations – Betaine HCL/Pepsin


Pure Encapsulations – Betaine HCl/Pepsin is another good betaine supplement with digestive enzymes. It includes additional support of the enzyme pepsin.


  • Hypoallergenic
  • Vegetarian

What’s in it:

  • 520mg betaine HCl
  • 21mg pepsin

Who makes it: Pure Encapsulations is a nutritional supplement producer that specializes in producing hypoallergenic products that are free from additives and fillers. Their products are research-based and designed to provide the consumer with effective results that are desirable and predictable. Their products are some of the most pure supplements that come in capsule and tablet forms.

Where to Get It

Frequently Asked Questions About Betaine Supplements

What is Betaine?

Betaine, also known as trimethylglycine (TMG), is an amino acid that is a derivative of the nutrient compound choline. Other names for betaine include betaine anhydrous, or trimethylglycine (TMG).

The combination of choline and the amino acid glycine can result in the formation of betaine. Its main function in the body is that of an osmolyte, which means it protects cells, proteins, and enzymes from environmental stress such as extreme temperatures, low water supplies, and high salinity.

Considered a “methyl donor,” it aids in liver function, detoxification, and healthy cellular function; and its most important function in the body is to help the body process fats. It also is involved in the process of producing carnitine in the body, which is an amino acid that plays a role in energy production and is also found as a stand-alone in quality carnitine supplements.

Homocysteine is an amino acid that most people obtain from eating meats. High levels of homocysteine are linked to early development of heart disease, renal disease, and low levels of vitamins B6, B12, and folate.

Betaine can be found naturally in shellfish, spinach, beets, broccoli, and grains. It is naturally present in many wheat products.

What Are the Uses & Benefits of Betaine?

Betaine is a methyl donor and an osmolyte, which means it offers many different health benefits as a dietary supplement. A methyl donor donates a methyl group (one carbon connected to three hydrogen atoms, CH3) which kickstarts a methylation reaction, whereas removing a methyl group stops a reaction.

There are hundreds of these reactions that occur throughout the body, and they can result in the detoxification reactions, as well as the production of serotonin and melatonin.

Benefits of betaine related to methylation include:

  • Detoxifying the body
  • Helping improve sleep quality
  • Supporting athletic performance
  • Supporting good energy levels
  • May help support mental health
  • May help reduce needs for SSRIs
  • Supports fat metabolization
  • Helps reduce health problems with aging
  • FDA certified to treat homocystinuria
  • May reduce homocysteine levels in those without homocystinuria
  • May reduce the risk of heart disease and stroke
  • Supports healthy energy production
  • May improve digestion of phenols

As an osmolyte, betaine protects the health and integrity of your cells. An osmolyte is a compound that affects osmosis, which is a cellular process in which a solvent tends to pass through a semipermeable membrane from a more concentrated solution to a less concentrated solution, equalizing the solutions on either side. Osmolytes are solvents in the solution, and they help maintain cell volume and balancing of fluids.

The benefits of betaine as related to its function as an osmolyte includes:

  • Supports health and integrity of cells
  • Protects proteins and enzymes
  • Supports kidney function
  • Protects the renal medullary cells in the kidneys
  • Helps the body process high levels of salt
  • May reduce the risk of kidney stones
  • Helps the body to handle environmental stresses

Other benefits of betaine supplements include:

  • Helps support proper digestion
  • Promotes stomach acid production
  • May help hypochlorhydria
  • Helps support mineral and nutrient absorption
  • May help acid reflux
  • May help fight candida and yeast infections
  • May reduce acne breakouts
  • May increase muscle strength and power
  • Helps increase creatine production
  • Supports overall health

As you can see, betaine has many benefits for your health as a supplement. Basically, it helps your body function smoothly and protects your health. Anyone can benefit from the best betaine supplements.

Who Can Benefit from Betaine?

  • Athletes – Betaine may help enhance athletic performance. It is often used as an ingredient in the best pre-workout supplements and the best post workout supplements to enhance muscle strength and power, as well as support a lean body composition. It does this through the methylation of homocysteine, which forms methionine. Methionine is an important biochemical component to the synthesis of creatine. This extra methionine production also increases protein synthesis in a process known as translation. A study at the University of Connecticut found that athletes that take 1.25 grams of betaine twice a day increased their muscle strength by 25%, and muscle power by 20%.
  • Those with Homocystinuria Homocystinuria is a genetic condition in which the body is unable to process certain amino acids and is caused by a mutation in the CBS, MTHFR, MTR, MTRR, and MMADHC genes. Homocystinuria disrupts the process of converting homocysteine into methionine, and results in increased levels of homocysteine in the blood which can harm health. Betaine is FDA approved for homocystinuria.
  • Those with Hypochlorhydria – Hypochlorhydria is a condition in which the body does not produce a sufficient amount hydrochloric acid (HCL), also known as stomach acid. This results in a lower stomach pH and gastrointestinal issues such as bloating, cramps, gas, indigestion, IBS, and more. Betaine HCL can help hypochlorhydria by supplementing HCL levels.
  • Those with Liver Issues – Liver disease includes any condition that damages the liver or prevents it from functioning properly such as nonalcoholic fatty liver disease, cirrhosis of the liver, hepatitis A, B, and C, hemochromatosis, and more. Some studies have found that betaine may help liver disease. One study suggests that betaine can “halt or reverse progression of the disruption of liver function.”
  • Those with Heart Issues – Heart disease is an umbrella term for cardiovascular conditions such as high blood pressure, congestive heart failure, cardiac arrest, peripheral artery disease, and more. Betaine can help heart disease by reducing levels of homocysteine in the blood. High levels of homocysteine is associated with heart disease and stroke.

Note: We do not condone using betaine for any issue without consulting your doctor first.

How Do I Take Betaine?

Betaine dosages vary on your purposes and/or health conditions. You should consult a doctor to determine the right dosage regimen for you. If you are taking it as a dietary supplement, generally around 650mg is an effective dose, but betaine dosages may range.

There are two types of betaine: Betaine HCL and betaine and betaine anhydrous. Betaine HCL should not be taken on an empty stomach because of its HCL attachment. Betaine anhydrous may be taken on an empty stomach.

Can I Stack Betaine With Other Supplements?

Betaine is a very stackable supplement and complements many other supplements to produce desired effects for athletes. Here are some beneficial betaine stacks:

Are There Any Side Effects of Betaine?

Betaine may cause gastrointestinal side effects such as bloating, nausea, diarrhea, and stomach upset. These side effects are more common with betaine HCL because of the hydrochloride attached to it. In general, if used correctly betaine should not cause too many unwanted side effects.

How Do I Pick a Good Betaine Product?

When searching for a high-quality betaine supplement, you should be aware of your personal purposes for the supplement. If you are taking betaine for its digestive benefits, you should make sure that you get a betaine HCL supplement rather than a betaine anhydrous supplement.

If you want more freedom to take your betaine supplement with or without food, you should make sure you get a betaine anhydrous supplement.

You should also evaluate the betaine dosage that the supplement provides. Generally, an effective betaine dosage is accepted to be about 500mg or more. While you are checking out the supplement facts, check the other ingredients. The fewer fillers the better.

If you are a vegetarian, there are vegetarian betaine supplements available and you should ensure that the label explicitly states that it is a vegetarian product.

Besides what is in the supplement, you also need to think about who made the supplement and how much it costs. A reliable manufacturer is an important component in a good betaine formulation.

You can identify a reliable and transparent producer by doing a little research on their company.

Generally, the best brands will say that they are certified or registered through some sort of reliable third party, such as the FDA or they will have a GMP certification. When evaluating the costs of the product, think about quality and quantity in comparison to other products. Look for the best product at a fair price.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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