Joint & Bone Glucosamine

Top 10 Glucosamine Supplements for 2022

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Have you ever complained about achy joints?

Pains in your joints and bones can be a result of wear and tear on the body, aging, not consuming enough bone and joint strengthening nutrients, cartilage loss, arthritic conditions and more.

Aging adults can attest to the importance of bone and joint health because almost 50% of those 65 and older have arthritis.

Your skeletal system includes 206 different bones and is the framework of your body. It structures your body and allows you to move in a variety of ways while protecting your internal organs.

Improving the health of your bones and joints at all ages can help improve your overall health and quality of life.

There is a supplement on the market that can help support the overall health of your bones and joints; It is called glucosamine.

In order to help you find a good product, we’ve researched & compared the best glucosamine supplements on the market right now.

10 Best Glucosamine Products Compared

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1. Schiff Glucosamine

Schiff Glucosamine

Schiff Glucosamine offers a high dose of glucosamine hydrochloride, a form of glucosamine that has evidence of being the most bioavailable form. It provides all of the benefits of glucosamine in easy to consume coated tablets. This particular formula also includes hyaluronic acid. It is classified as a glycosaminoglycan, which is a long chain of sugars that is part of the connective tissues of the body, including the joints.

What’s in it:

  • 2000mg glucosamine hydrochloride
  • 3mg hyaluronic acid

Who makes it: Schiff is one of the oldest companies in the nutritional supplement industry and was founded in 1936. They pride themselves on high quality and effective ingredients, and they follow stringent quality control protocols, including marking their products with expiration dates to ensure freshness. In their manufacturing, they follow GMP protocols as well. Their brands include Megared, Move Free, Digestive Advantage, and Airborne.

Where to Get It

2. Doctor’s Best Glucosamine/Chondroitin/MSM


Doctor’s Best Glucosamine/Chondroitin/MSM uses three of the best joint support ingredients available, providing synergistic health benefits. It also utilizes glucosamine sulfate; the most highly studied form of glucosamine.

Chondroitin is a naturally occurring substance in the connective tissues of the body and is more often used in conjunction with glucosamine because of their positive interactions. Altogether, this formula is an effective glucosamine supplement with the support of chondroitin and MSM.

What’s in it:

  • 750mg glucosamine sulfate
  • 600mg chondroitin sulfate
  • 500mg methylsulfonylmethane (MSM)

Who makes it: Doctor’s Best is a nutritional supplement company that was founded by physicians in 1990. With their medical knowledge and expertise, they developed high-end health supporting supplements using scientifically-backed, effective ingredients. Their manufacturing facilities follow strict GMP protocols. You know exactly what is in their products due to their commitment to transparency and medical science.

Where to Get It

3. NOW Foods Glucosamine 1000

Now Foods Glucosamine 1000

NOW Foods Glucosamine is a pure glucosamine hydrochloride supplement in the form of glucosamine pills. This form of glucosamine is said to be the most bioavailable form, giving it a higher potency. It has a highly effective dose of 2000mg per serving (which is two pills).

Made by one of the leading natural supplement brands, NOW foods, it is an all-natural glucosamine supplement. If you are looking for pure, all-natural glucosamine at an affordable price, this is a good glucosamine product for you.

What’s in it:

  • 2000mg glucosamine hydrochloride

Who makes it: NOW foods is a natural supplement manufacturer that has been a leader amongst the natural supplements industry since 1968. They pride themselves on using top quality and effective ingredients and sustainable production, and their ingredients are all traceable to the source. Their manufacturing facility in Sparks, Nevada landed the LEED Silver certification for sustainability, and the company itself has been given numerous awards for quality and health.

Where to Get It

4. Bluebonnet Glucosamine Chondroitin Plus MSM

Bluebonnet Glucosamine Chondroitin Plus Msm

BlueBonnet Glucosamine Chondroitin Plus MSM is a quality glucosamine supplement that provides optimum benefits. This product supplies you with a quality joint support formula of glucosamine, chondroitin, and MSM.

Methylsulfonylmethane (MSM) is an antioxidant substance that comes with antioxidant benefits. It is made by a reliable company that produces top-quality nutritional supplements with effective ingredients. This product is a great joint support supplement, however, it is three capsules per serving, which is not always desirable to consumers.

What’s in it:

  • 1000mg glucosamine sulfate
  • 500mg chondroitin sulfate
  • 500mg methylsulfonylmethane (MSM)
  • 500mg vitamin C

Who makes it: BlueBonnet is a natural supplement company that has been around for 25 years, producing farm-to-table products. Many of their supplements are vegetarian, gluten-free, non-GMO, allergen-free, kosher, and more. Many are also USDA certified organic. Each product is labeled according to its special consumer accommodations. If you have a special dietary restriction or need, BlueBonnet is a great company for you.

Where to Get It

5. Nature’s Way Glucosamine


Nature’s Way Glucosamine is a tablet that uses both glucosamine and methylsulfonylmethane (MSM). MSM fortifies these benefits with its anti-inflammatory and antioxidant properties. This product is an effective glucosamine choice made by a reliable company and can be found at an affordable price.

What’s in it:

  • 1050mg glucosamine sulfate potassium chloride (contains 750mg glucosamine sulfate)
  • 750mg methylsulfonylmethane (MSM)

Who makes it: Nature’s Way is a natural supplement company that has been supplying consumers with herbal remedies and natural supplements for over 40 years. The founder, Tom Murdock, had a sick wife and traditional western medicine was not helping.

Murdock then looked to native American herbal medicine to improve her health, and with that, she lived another 25 years. Inspired by this, he founded Nature’s Way. Their TRU-ID certification shows that what is on the supplement facts is truly what is in the supplement.

They are also proud partners in the non-GMO project, which means they strive to reduce the use of genetically modified foods.

Where to Get It

6. Nutrilite Joint Health – Glucosamine and Chondroitin

Nutrilite Joint Health - Glucosamine and Chondroitin

Nutrilite Joint Health – Glucosamine and Chondroitin uses chondroitin in conjunction with glucosamine to strengthen its benefits. It not only includes chondroitin, but also utilizes hyaluronic acid, MSM, and many other ingredients.

Ultimately, it provides a lot of glucosamine benefits with high quality and effective ingredients, making it a good product. It is produced by a very reliable company that uses top quality ingredients straight from their own certified organic farms.

However, this particular product uses a proprietary blend, meaning that you do not know how much of each ingredient is actually in a serving. It also is more expensive than some alternatives.

What’s in it:

  • 750mg glucosamine sulfate
  • 890mg proprietary blend consisting of MSM, chondroitin, boron glycinate, manganese amino acid chelate, and hyaluronic acid
  • 50mg boswellia serrata extract
  • 15mg vitamin C
  • 5mg acerola concentrate
  • 2mg citrus bioflavonoids

Who makes it: Nutrilite is a vitamin and mineral brand that uses science and nature to create outstanding products. Their claim to fame is that they are the only vitamin and mineral brand in the world to grow, harvest, and process plants from certified organic farms of their own.

Every product they produce has been subject to extensive research from their team of over 200 experts in the sciences before being sold. They are ultimately dedicated to helping others lead healthier lives.

Where to Get It

7. Nature’s Bounty Maximum Strength Glucosamine


Nature’s Bounty Maximum Strength Glucosamine is a pure glucosamine supplement. At a glucosamine dosage of 1500mg per capsule, you are getting 3000mg per serving. Using glucosamine hydrochloride, these dissolvable capsules are also highly bioavailable.

This product does not use any preservatives, milk, soy, gluten, wheat, yeast, sodium, artificial flavors or sweeteners. The product advises that it be taken daily with food for four to six weeks for results. Made by Nature’s Bounty, this is an overall good product.

This is a reliable product manufactured by a reliable health and wellness company. It provides you with a very high dosage of bioavailable glucosamine and is fortified with vitamin D. However, this high glucosamine dosage is not necessary to attain results.

What’s in it:

  • 3000mg glucosamine hydrochloride
  • 400 IU vitamin D

Who makes it: Nature’s Bounty is the flagship brand of Nature’s Bounty Co., which also includes brands Optimal Solutions, Earthly Elements, and Nature’s Bounty Rewards. Founded in 1971, this health and wellness brand has been providing consumers with products that meet stringent Quality Assurance Standards and GMP standards. Their facilities have also been tested and approved by the United States Pharmacopeia and Specialized Technology Resources (STR).

Where to Get It

8. Solaray Glucosamine Sulfate


Solaray Glucosamine Sulfate is your basic glucosamine supplement that is great for someone who has never tried one. It is affordable and uses the most studied form of glucosamine at a reasonable dose, providing you with the basic glucosamine benefits.

This product is good for trying out glucosamine because it provides you pure and simple glucosamine sulfate. If you have never taken glucosamine before, you can try to see whether or not the supplement works for you.

However, there are products in the same price range that may be more bioavailable, and more potent. There are also products in the same price range that are fortified with other joint supporting vitamins and ingredients.

What’s in it:

  • 1500mg glucosamine sulfate

Who makes it: Solaray is a nutraceutical brand that was founded in Utah in 1973, and acquired in 1993. It is known for herbal-based health products, with five herbal categories denoted by lid color and 460+ different products.

They use laboratory analysis to ensure that the supplement facts disclose exactly what is in their product, and for purposes of quality control. They also do potency and purity testing. Overall, Solaray is one of the leading natural supplement brands in the industry.

Where to Get It

9. Twinlab Glucosamine Sulfate


Twinlab Glucosamine Sulfate is another basic glucosamine supplement that provides consumers with glucosamine benefits. One easy to swallow capsule contains 750mg of glucosamine sulfate, for a serving size of 1500mg (two capsules). It is packaged in a glass bottle to ensure quality and freshness.

This is a great entry-level glucosamine supplement that provides you with an effective glucosamine dosage and a reliable product. However, it is a bit more expensive than alternatives for what it offers. As far as value, there are more potent forms of glucosamine supplements available, and there are also products at the same price range.

What’s in it:

  • 1500mg glucosamine sulfate

Who makes it: Twinlab was founded in 1968 by David Blechman, a man with 20 years of experience in the pharmaceutical industry. He started the company out of his garage, with his wife who was pregnant with twins, and named it Twinlab because of the twins that were on the way. Currently, they produce products such as vitamins, minerals, herbs, and teas.

Where to Get It

10. Thorne Research Glucosamine and Chondroitin

Thorne Research Glucosamine And Chondroitin

Thorne Research Glucosamine and Chondroitin is a product that uses the synergistic benefits of glucosamine and chondroitin. However, there are products that provide consumers with better value. This supplement is a bit more pricey than other choices.

What’s in it:

  • 500mg glucosamine sulfate complex (includes potassium and chloride)
  • 250mg chondroitin sulfate

Who makes it: Thorne Research was founded in Seattle, Washington in 1984 as a nutritional supplement brand. Its very first product was Pure Ascorbic Acid, which is vitamin C and is beneficial to supporting immune system health. Since its inception, it has been dedicated to providing quality, effective, cutting edge products that are backed by scientific research.

Where to Get It

Frequently Asked Questions About Glucosamine Supplements

Importance of Joint Health

To understand how glucosamine can benefit joint health, you must understand what joints are, what they are made of, and how they function. Joints are connections between bones in your body, and the ones we will be focusing on are mobile joints.

They include cartilage, which is a firm yet flexible and rubbery connective tissue. Surrounding the joint is usually fibrous connective tissue called ligaments. Joints are lubricated in order to allow smooth motion by a synovial membrane that produces the lubricant, synovial fluid.

Joint health can be affected by age and the amount of physical activity. Inactivity can result in degraded joint health because cartilage can absorb residual synovial fluids and reduce the joints lubrication.

This lack of synovial circulation can result in damage to joints. On the other end of the spectrum, lots of activity can wear down on cartilage, reducing cartilage and harming joint health. Aging has the same effect over a longer time period. Glucosamine can support joint health by addressing these things.

What is Glucosamine?

It is a substance made from sugars and proteins bound together that can be found in some food sources, such as bone broth and the shells of crustaceans such as shrimp, lobster, and crab. It can also be derived from certain vegetable sources for supplemental purposes. It is also produced in the human body and plays a key role in building cartilage. It was originally used as a supplement for racehorses to strengthen their joints and bones for the race tracks.

Glucosamine helps to increase the amount of cartilage that surround your joints and improve synovial fluid viscosity, which protects them from wear and tear. It also helps to form connective tissues that are necessary for your joints and your digestive linings, meaning that it also may have beneficial health effects on the digestive system.

It helps to form cartilage and connective tissues by creating long chains of glycosaminoglycans, which are the building blocks of cartilage. Chondrocytes, collagen, and glycosaminoglycans make up cartilage.

There are three forms of glucosamine, two of which glucosamine supplements typically utilize.

Glucosamine sulfate, which is the most studied form, has been found to be capable of controlling symptoms of osteoarthritis according to several studies.

It can also be found in the form of glucosamine hydrochloride, which has not been as extensively studied. However, there is evidence that glucosamine hydrochloride may be more bioavailable than glucosamine sulfate. Some glucosamine hydrochloride supplements are derived from vegetable sources, and these are known to have more gastrointestinal side effects.

The third form of glucosamine, N-acetyl glucosamine, is sourced directly from shellfish and can be used to make chitosan. It is not commonly used as a glucosamine supplement.

Glucosamine hydroiodide is another available form that is usually not used for supplementation. In total, there are four forms of glucosamine.

What Are the Uses & Benefits of Glucosamine?

There are many major benefits of glucosamine that can help your health. All of these benefits can be very effective for improving quality of life, longevity, and physical health.

  • Help to reduce inflammation
  • Help to improve cartilage health
  • Help improve immune system health
  • Can reduce the risk of osteoarthritis and rheumatoid arthritis
  • Help reduce osteoarthritic pain
  • Help reduce joint swelling and stiffness
  • Help to improve bone strength and density
  • May improve knee function in those with knee osteoarthritis
  • Can provide osteoarthritis pain relief up to 3 months after treatment is stopped
  • May help treat rheumatoid arthritis
  • Can ease symptoms of TMJ disorder
  • May help inflammatory bowel disease
  • May help leaky gut syndrome
  • Improves digestive health
  • Can improve healing of fractures

Improves overall health

Some people can benefit from glucosamine to a greater degree than others. In the next section, we will discuss who can benefit from top glucosamine supplements.

Who May Benefit from Glucosamine?

This list examines the types of people who may have increased benefits from glucosamine supplements.

  • Those who are young – Young people can most greatly benefit from glucosamine through the preservation of joint health. When most people are young, their joints and bones and cartilage are fairly healthy because they have not been worn down over time. As you age, moving a lot, or not moving enough, can take a toll on the condition of your cartilage and synovial fluids. Your cartilage can be ground down, lose its rubbery cushion, stiffen and harden. Your synovial fluid in your joints can lose its viscosity, therefore reducing its lubricating effects on your joints. Glucosamine preserves the rubbery cushion of your cartilage and connective tissues and the viscosity of your synovial fluid.
  • Those who are old – Taking glucosamine supplements in your elder years can help to rejuvenate the health of your joints and connective tissues, resulting in improved overall health and reduced joint pain. Glucosamine can stimulate cartilage growth to counteract damage from wear and tear, and it may help improve the viscosity of the synovial fluid in your joints.
  • Those with osteoarthritis – Those who have osteoarthritis, or OA, can benefit from taking glucosamine. OA is a condition in which aging and use of joint wear and tear on cartilage over time, reducing the cartilage in between joints and causing pain, stiffness, reduced mobility, and swelling. Glucosamine sulfate has been studied for its effectiveness in reducing symptoms of pain in patients with OA, and studies have shown it may reduce patients’ needs for NSAIDs. This means that patients with OA can supplement with glucosamine, a natural alternative, to reduce the dosage of pain medications they need. It has also been found to help pain up to three months.
  • Those with rheumatoid arthritisRheumatoid arthritis, or RA, is an autoimmune disease that causes chronic inflammation of the joints in the body. Glucosamine is less effective for RA than it is for OA but can help to reduce inflammation. By reducing inflammation, glucosamine may slightly reduce joint pain and stiffness in patients with RA, reducing the dosages of pain medication they may need.
  • Those with TMJ disorderTMJ disorder, otherwise known as a temporomandibular joint disorder, is a disorder that causes pain and reduced mobility of the jaw. Symptoms include pain in the jaw, neck, and shoulders, trouble chewing, problems opening the mouth, toothaches, headaches, and more.
  • Those who are overweight – Being overweight or obese puts a lot more strain on your joints and bones, increasing the likelihood of developing OA and RA. Glucosamine can be particularly beneficial at reducing wear and tear on joints by improving synovial fluid viscosity and cushioning of cartilage.
  • Those who are athletes – Athletes also put an increased strain on their joints, causing more wear and tear on cartilage and joints and putting a lot more strain on joints and bones. Taking glucosamine can support the health of your joints. It can also help reduce joint pain from exercise and exertion, helping to improve athletic performance and endurance.

As you can see, glucosamine can help those who are at a higher risk of developing arthritis to reduce their risks. It can also help reduce symptoms of OA and RA, and regular joint pain from exertion.

How Do I Take Glucosamine?

Glucosamine can be taken differently for different purposes and depending on the form of glucosamine in the supplement. Many experts advise that you take any glucosamine supplement with food to improve its bioavailability. In general, the best way to take a glucosamine supplement is to read and follow the directions on the product you are using.

Are There Any Side Effects of Glucosamine?

Glucosamine side effects are not common, but some may experience gastrointestinal side effects such as nausea, diarrhea, intestinal gas, and heartburn. These side effects are cited more commonly with glucosamine supplements that use glucosamine hydrochloride from a vegetable source. Other side effects are possible but uncommon.

How Do I Pick a Good Glucosamine Product?

When looking for a high-quality glucosamine supplement, a consumer should pay attention to a couple of things. The first thing that should be examined is the supplement facts, which will tell you how much and what kind of glucosamine is in the supplement. It will also identify other ingredients if there are any. You should ensure that it tells you the form of glucosamine, and how much there is per serving.

Second, the consumer should pay attention to the manufacturer. Researching the brand can teach you about the supplement in question, and how high quality and reliable the product is. Good quality brands will be open and transparent about their products and ingredients.

Finally, the consumer should examine the price. It is good to know the prices of multiple products on the market so that you can familiarize yourself with what a good price is for the product. This guide will address the supplement facts, manufacturers, and value of a product in depth.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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