Energy Nitric Oxide

Top 10 Best Nitric Oxide Supplements For a Killer Pump in 2022

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In order to help you find a good product, we’ve researched & compared the best nitric oxide supplements on the market right now.

10 Best Nitric Oxide Products Compared

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1. Cellucor NO3 Chrome

Cellucor No3 Chrome

Cellucor NO3 Chrome is a powerful nitric oxide supplement. With an effective dose of arginine, plus a vascularity complex consisting of citrulline, arginine and grape seed extract, this product is designed to be a solid NO product.


  • Loaded with arginine, citrulline malate and grape seed extract
  • Uses patented NO3-T (arginine nitrate)
  • Creatine-free
  • Stimulant-free
  • Great value
  • Nitric oxide in pill form for convenience

What’s in it: One serving contains:

  • 25g arginine nitrate (a combination of L-arginine and nitrate)
  • 750mg extreme vascularity complex, consisting of Nitrosigine arginine silicate, citrulline malate, and grape seed extract

Who makes it: This product is made by Cellucor, a large and well-respected supplement company that specializes in workout supplements. Best known for their C4 pre-workout supplement, Cellucor now makes a wide range of helpful products aimed at athletes and bodybuilders. They pride themselves on consistency and quality, and their large size allows them to keep prices low and quality high. They value all of their customers greatly, and even offer a money-back guarantee on all their products.

Bottom line: It uses a pure, simple and highly effective formula. It comes in the form of nitric oxide pills, which are very convenient and easy to take. We also recommend this product highly because it’s made by Cellucor, one of the best-known brands in the business.

Where to Get It

2. BSN Nitrix 2.0

Bsn Nitrix 2

BSN Nitrix 2.0 is a strong nitric oxide supplement that combines L-citrulline, hawthorn extract, creatine and more to provide a potent workout booster in one convenient package. Nitrix 2.0 is a potent all-around workout booster, and one of our top recommendations.


  • Loaded with L-citrulline, creatine and more
  • Uses 3 different kinds of creatine
  • Easy to take
  • Good value

What’s in it: One serving contains:

  • 6g BSN Nitrix 2.0 proprietary blend, consisting of L-citrulline, hawthorn extract, pomegranate fruit, grape seed extract, resveratrol, and more.
  • Myogenic matrix, consisting of creatine monohydrate, creatine HCI, and creatine anhydrous

Who makes it: This product is made by BSN, which stands for Bio-Engineered Supplements and Nutrition. Founded in 2001, BSN has quickly become a global leader in the supplement industry, producing cutting-edge, effective and affordable supplements. Their focus is on the athletic supplement industry, and their motto is “Finish First” – something they intend to help all their customers do. BSN is a trustworthy and professional brand with excellent products.

Bottom line: It may help improve the results you see from your workouts in many ways. Add that to the fact that it comes from a reliable brand like BSN, and you’ve got yourself a great NO product.

Where to Get It

3. Transparent Labs PreSeries BULK

Transparent Labs Preseries Bulk Pre Workout

Transparent Labs PreSeries BULK is a powerful pre-workout supplement and nitric oxide booster. It’s designed for those who are in a “bulk” cycle, trying to gain muscle mass and power. With the help of an all-star cast of ingredients, including citrulline malate, beta-alanine, BCAAs, betaine, taurine, caffeine, theanine, and more.


  • Loaded with BCAAs, citrulline, beta-alanine, taurine and more
  • 19 active ingredients
  • Clinically effective dosages of all ingredients
  • Caffeine for an immediate energy boost
  • No unnecessary fillers, additives, or colored dyes
  • Made by a great company
  • 100% label transparency
  • Excellent value

What’s in it: One serving contains:

  • 6g citrulline malate
  • 4g beta-alanine
  • 4g BCAAs (branched-chain amino acids)
  • 5g betaine anhydrous
  • 3g taurine
  • 600mg tyrosine
  • 360mg L-theanine
  • 180mg caffeine anhydrous
  • Much more!

Who makes it: This product is made by Transparent Labs, a large scale manufacturer of fitness supplements and health aides. As their name suggests, Transparent Labs prides itself on complete transparency – they always list every ingredient used, in full detail, and they include those ingredients at clinically effective dosages. You won’t find proprietary blends or unnecessary additives in Transparent Labs products, and PreSeries BULK is no different!

Bottom line: It’s an all-around pre-workout booster, which is effective at improving NO levels as well as energy and endurance abilities.

Where to Get It

4. Pro Supps NO3 DRIVE

Pro Supps No3 Drive

Pro Supps NO3 DRIVE combines L-citrulline, agmatine, carnitine, ginseng and more. And since this supplement comes in nitric oxide pill form, they are convenient and easy to use.


  • Combines citrulline, carnitine, ginseng, agmatine and more
  • Made by a well-respected company
  • Good value

What’s in it: One serving contains:

  • 700mg vasodilation matrix, consisting of L-citrulline, agmatine sulfate, rutaecarpine and more
  • 527mg GPLC matrix, consisting of GlycoPro and GlycoCarn
  • 110mg enhanced nutrient absorption matrix

Who makes it: This product is made by Pro Supps, a large supplement manufacturer founded in 2004. With over a decade of experience, Pro Supps is dedicated to creating the highest quality products possible. Each year, they dedicate significant time and money to the research and development of new products, in order to stay on the cutting edge of exercise science.

Bottom line: It combines many of the top ingredients that are effective at improving exercise performance through increased nitric oxide and it’s conveniently packaged in pill form. With that said, the use of proprietary blends makes it difficult to know the exact quantity of each ingredient you’re getting, and whether or not those ingredients are included at effective dosages.

Where to Get It

5. Universal Nutrition Animal Pump Pre-Workout


Universal Nutrition Animal Pump Pre-Workout is a strong pre-workout supplement formulated for optimal exercise performance. Animal Pump contains several key NO-boosting ingredients, including arginine, beta-alanine, taurine and more – as well as creatine, caffeine, guarana and more. This can be an effective way to increase nitric oxide levels, while also providing energy and drive to power your best possible workout.


  • Loaded with arginine, beta-alanine, ornithine and more
  • Creatine blend for increased strength and endurance
  • Energy blend (with caffeine) for increased performance
  • Antioxidant blend
  • Complete pre-workout solution
  • Good value
  • Convenient packets make on-the-go use easy

What’s in it: One serving contains:

  • 3g creatine matrix, consisting of creatine MagnaPower, CreaPure, creatine gluconate, and more
  • 2g NO blast matrix, consisting of Arginine-AKG, Ornithine-AKG, beta-alanine, and more
  • 500mg energy rush matrix, consisting of caffeine, kola nut powder, and guarana powder
  • 700mg antioxidant complex, consisting of green tea extract, grapeseed extract and more
  • 1g pump transport complex, consisting of taurine, ginger root, and more

Who makes it: This product is made by Universal Nutrition, one of the largest supplement manufacturers in the business. Founded way back in 1977, Universal Nutrition has dedicated decades to the research and development of cutting-edge fitness supplements. Today, they offer a huge number of high-quality products, mostly marketed towards bodybuilders and fitness enthusiasts.

Bottom line: It does contain several NO boosting ingredients, so it is an effective nitric oxide booster. However, the use of proprietary blends is a definite downside, as it’s impossible to tell exact quantities of each ingredient.

Where to Get It

6. Promera Health Pump Extreme

Promera Health Pump Extreme

Promera Health Pump Extreme is a good nitric oxide supplement from a good company. It contains a lot of the key ingredients that are most effective at increasing NO production, and it’s available in a variety of flavors. The only real downside is the use of a proprietary blend.


  • Caffeine for extra energy
  • Increased nitric oxide production
  • An all-around workout booster
  • Powder form, available in several flavors
  • Affordable

What’s in it: One serving contains:

  • 3,051mg vaso support matrix, consisting of Arginine Alpha-Ketoglutrate, Citrulline HCI, Agmatine Sulfate, L-Norvaline, Pine Bark Extract
  • 20mg Niacin
  • 200mg PurCaf caffeine

Who makes it: This product is made by Promera Sports, a fitness supplement company founded in 2007. With a decade of industry experience, Promera’s line of products has now expanded into more than 40 different supplements, aimed at helping bodybuilders and athletes reach their fitness goals. They hold several exclusive patents and are best known for their CON-CRET line of fitness products.

Where to Get It

7. Cellucor C4

Cellucor C4 Original

Cellucor C4 is a popular pre-workout supplement with nitric oxide boosting ingredients. In fact, it’s perhaps the most popular one out there, with millions of units sold every year. Cellucor C4 combines creatine, nitric oxide, beta-alanine, arginine, caffeine and more to create a potent all-around workout booster.


  • Loaded with creatine, beta-alanine, arginine, and more
  • Caffeine and tyrosine for added energy
  • Ramps up NO production
  • Very affordable

What’s in it: One serving contains:

  • 6g beta-alanine
  • 1g creatine nitrate
  • 1g arginine AKG
  • 371 explosive energy blend, consisting of tyrosine, caffeine, and more

Who makes it: This product is made by Cellucor, a well known and well-respected supplement manufacturer. They produce a wide range of useful supplements, including our #2 overall recommendation on this list. All their products are developed by industry experts, and they back their offerings with a 100% money-back guarantee.

Bottom line: Overall, if you’re looking for a pre-workout booster that also offers a good amount of NO-boosting ingredients, Cellucor C4 is a good option. The only real downsides are that it is sweetened with artificial sweeteners that some people may want to avoid.

Where to Get It

8. MusclePharm Assault Pre-Workout

Musclepharm Assault

Muscle Pharm Assault Pre-Workout is an all-in-one workout booster combining beta-alanine, tyrosine, creatine, taurine and more. It’s designed to deliver intense energy for your workout, without the crash afterward, while also boosting NO production. It’s also a very affordable option, and completely free of fillers and artificial dyes.


  • Loaded with beta-alanine, arginine, tyrosine, creatine, taurine and more
  • Provides explosive energy, without the crash
  • Boosts NO production
  • A complete pre-workout solution
  • Affordable

What’s in it: One serving contains:

  • 3,500mg ATP Amplifier, consisting of beta-alanine, L-tyrosine, and more
  • 2,952mg cellular transport & insulin activator, consisting of dextrose, L-glycine and more
  • 2,000mg athlete performance blend, consisting of creatine nitrate, L-arginine nitrate, BCAAs, and more
  • 1,750mg energy & neuro igniter, consisting of choline bitartrate, caffeine, huperzine A and more
  • 1,200mg hydration system, consisting of taurine, coconut water powder, and L-glutamine

Who makes it: This product is made by MusclePharm, a well-known supplement manufacturer founded in 2008. MusclePharm has rapidly grown in popularity in a short period of time, now offering its products to citizens of more than 110 countries. They have won numerous awards along the way for the innovative products, and are well known for being one of the higher quality yet low-cost providers of fitness supplements.

Bottom line: It’s one of the more popular pre-workout blends out there, it’s offered by a good company, and it’s sold at an affordable price. With that said, the product does use a proprietary blend, and its overall reviews are mediocre.

Where to Get It

9. Irwin Naturals Nitric Oxide Pre-Sport


Irwin Naturals Nitric Oxide Pre-Sport is a potent pre-workout booster that combines a number of unique ingredients in order to make an effective fitness supplement. It uses some standard fitness boosters, like L-citrulline and L-theanine, and some unique ingredients like medium-chain triglyceride oil, ginkgo extract, cayenne powder, and yerba mate powder. It’s also the only product on this list sold in liquid gelcap format, so it’s certainly a unique option.


  • Unique formula
  • Contains L-citrulline and L-theanine
  • Unique ingredients like yerba mate powder, ginkgo biloba extract, MGT oil & more
  • Boosts nitric oxide production
  • Liquid gel caps
  • Made by a great company
  • Very affordable

What’s in it: One serving contains:

  • 1,000mg medium-chain triglyceride oil (MCT oil)
  • 750mg L-citrulline
  • 60mg beet powder
  • 50mg L-theanine
  • 40mg ginkgo extract
  • 30mg cayenne powder
  • 20mg yerba mate powder
  • 62mg Asian ginseng extract
  • 3mg BioPerine black pepper extract (to improve absorption)

Who makes it: This product is made by Irwin Naturals, a natural supplement manufacturer with over 20 years of industry experience. Unlike most companies on this list, Irwin Naturals is more of a general-purpose supplement company, instead of a fitness-specific manufacturer. They make a wide range of all-purpose products, from vitamins to probiotics to fitness supplements. They are a well-reputed company with high-quality products.

Where to Get It

10. Pure Encapsulations – Nitric Oxide Ultra


Pure Encapsulations Nitric Oxide Ultra is a simple and effective nitric oxide booster containing a unique blend of L-citrulline, cranberry extract, and grape extract. The simple formula is also very gentle and easy on the stomach and only contains 3 active ingredients.


  • Simple formula
  • Gentle & pure
  • L-citrulline, cranberry extract and grape extract
  • Hypo-allergenic
  • No fillers or unnecessary ingredients

What’s in it: One serving contains:

  • 1,000mg L-citrulline
  • 382mg CranLoad proprietary blend, consisting of cranberry extract and grape seed extract

Who makes it: This product is made by Pure Encapsulations, a manufacturer of simple and pure supplements for a variety of applications. They focus on creating hypo-allergenic, filler-free products for the health and wellness industry. They avoid the use of artificial sweeteners, artificial colors, coatings, gluten, and other common allergens in all of their products.

Bottom line: Its limited ingredient profile is both a good and a bad thing; good, because it avoids many common allergens and unnecessary fillers, but bad, because it does not offer many of the most effective nitric oxide boosters. For the price, there are better options out there.

Where to Get It

Frequently Asked Questions About Nitric Oxide Supplements

What is Nitric Oxide?

Nitric oxide is a natural molecule that is naturally produced in our own bodies. It’s used to help facilitate communication between cells, by helping to transmit signals throughout our bodies.

Nitric oxide, commonly referred to as “NO”, is used for a huge variety of purposes within the body, but it’s primarily thought of for its strength and endurance-boosting properties.

What Are Nitric Oxide Supplements?

Nitric oxide supplements are a class of health product designed to boost nitric oxide production. They generally use a blend of ingredients, such as citrulline, arginine, beta-alanine, BCAAs, Taurine, Tyrosine, and more.

We’ll go over these ingredients in greater detail in the section below.

Generally, nitric oxide supplements will contain a blend of ingredients that is formulated to help boost your nitric oxide levels during workouts. This may help improve the quality, intensity, and duration of your exercise sessions, which in turn leads to better results. We’ll cover nitric oxide benefits in greater detail in a later section.

What Are the Ingredients Commonly Used in Nitric Oxide Products?

As mentioned, nitric oxide products use blends of several ingredients. There are a wide variety of ingredients used, but some of the most common are:

  • Arginine – L-arginine is an amino acid that is known to stimulate production of certain hormones, including growth hormones, which are key to muscle growth and energy levels. L-arginine is considered “semi-essential”, meaning that while the body can produce it on its own, supplemental L-arginine is beneficial to those who exercise regularly. L-arginine can also help to prevent inflammation, reduce high blood pressure, reduce muscle pain, improve athletic performance, and more. Arginine can be included in nitric oxide supplements on its own, or in the form of L-citrulline, as discussed below.
  • Citrulline – Citrulline is an amino acid that may help to improve energy levels and endurance in both aerobic and anaerobic exercise. The amino actually turns into L-arginine when it is taken in the form of a good citrulline supplement. This provides the benefits of L-arginine, and as it turns out, L-citrulline actually may be a more effective way to obtain more L-arginine when compared to actual supplemental L-arginine.
  • Branched Chain Amino Acids – Branched-chain amino acids, or BCAAs for short, are some of the most important amino acids for athletes and bodybuilders. This group consists of leucine, isoleucine, and valine. Combined, BCAAs have a number of key benefits, with the most notable being increased protein synthesis, which may lead to better muscle growth. Of the three, leucine is considered the most anabolic, having been found in clinical trials to be effective at boosting strength during workouts while stimulating muscle recovery and growth. BCAAs can be obtained through a diet rich in food products including meats and eggs, but they are most effective in their concentrated pure form, or as part of a good quality BCAA blend.
  • Beta-Alanine – Heralded for its ability to increase cellular carnitine levels during exercise, beta-alanine supplements may help to extend your workout endurance by replenishing lost carnitine stores. Essentially, beta-alanine helps to delay the onset of neuromuscular fatigue, leading to longer, more effective exercise sessions.
  • Creatine – If you’re into fitness at all, then you know that creatine is a really popular fitness supplement, and for good reason. Essentially, creatine helps to increase strength and fuel muscles once they have used up their stores of ATP, the primary energy source for human activity. In clinical trials, creatine has been shown to increase maximum power during exercise by up to 15%.

Some of the ingredients that are listed above and found in nitric oxide supplements do not necessarily boost nitric oxide levels directly, but are still effective at improving workout performance.

Often, nitric oxide supplements get grouped together with pre-workout supplements, as the two categories have a lot of overlap. Most nitric oxide products are best used before working out, essentially putting them into the pre-workout category.

Additionally, products marketed as high quality pre-workout blends generally contain nitric oxide-boosting ingredients.

What Are the Benefits of Nitric Oxide?

Nitric oxide supplements are designed to boost nitric oxide levels, which can lead to better, more effective workouts. This essentially helps to increase circulation, leading to your muscles getting more oxygen and more nutrients when they need it the most.

The benefits of nitric oxide go beyond that, however. Here are just a few:

Who Can Benefit from Nitric Oxide Supplements?

Nitric oxide supplements are mostly marketed towards bodybuilders and other fitness enthusiasts. In reality, a wide range of people can experience benefit from these products. Some key groups include:

  • Athletes – anyone who considers themselves an athlete – whether that means playing in the NBA or in a local softball league – can benefit from nitric oxide boosters. These supplements help primarily in the training stage, as they allow for longer, more intense and more productive workouts. Also, athletes put their muscles through some significant strain, so they can also benefit from the increased nutrient uptake to muscles offered by these products.
  • Weightlifters – whether you’re a casual weightlifter, a full-blown bodybuilder, a crossfitter or even a powerlifter, nitric oxide supplements can help on your path to the body you want. By improving workout quality and duration, these products can help you squeeze the most benefit out of your time in the gym, while helping increase muscle growth and strength gains.
  • Experienced Bodybuilders –  if you’re a regular gym-goer, you may have experienced what is referred to as an exercise plateau, which essentially means a sudden lack of further progress towards your goals. For example, many people may have a steadily increasing max bench press for the first year they are lifting, and then suddenly get “stuck” at 250lbs. It can be really difficult to push through these plateaus, but introducing a nitric oxide supplement can sometimes make a difference by giving your muscles the tools needed to break through those barriers.

Are There Any Side Effects of Nitric Oxide?

Nitric oxide side effects are possible for some people. Stomach upset and related gastrointestinal issues are some of the more commonly reported issues. If you notice stomach upset after taking an NO supplement, consider taking your next dose with food, or cutting down on the dosage size. Most NO supplements have a serving size of 2-3 nitric oxide pills, so it’s pretty easy to lower the dosage.

Since nitric oxide supplements affect the blood vessels, this can potentially lead to changes in blood pressure. For the most part, this translates to a lowering of blood pressure, which can potentially result in side effects such as headache, dizziness, nausea and vomiting. If you notice these symptoms, you should seek medical attention as low blood pressure can cause potentially serious symptoms down the line.

How Do I Pick a Good Nitric Oxide Product?

Most products these days, including nitric oxide supplements, offer a LOT of options. There are hundreds of products competing for your business, so why should you choose one or the other? You can also use the following factors to help you make a decision:

  • Included Ingredients – the first step when choosing the best nitric oxide supplement for you is to take a close look at the ingredient label. See what ingredients are included, and in what quantities. Refer to a previous section to learn more about the ingredients that are commonly included in these products.
  • Nitric Oxide Booster vs Pre-Workout – as we mentioned previously, there is somewhat of a blurred line between true nitric oxide supplements and general pre-workout boosters. Generally, nitric oxide blends don’t include creatine or stimulants like caffeine, while pre-workouts do. There’s nothing wrong with using pre-workout supplements (in fact, they are quite effective), but it’s good to be aware of the difference between the two. On our list of the best nitric oxide boosters, we’ve included both types of supplements but made an effort to note the difference.
  • Brand Quality – who makes the product? Are they well known and well respected? On our list of the best nitric oxide supplements, we’ve exclusively used products from well-reputed companies. However, if you shop elsewhere, make sure you do some research on the companies you’re buying from before making a purchase.
  • Value – if you workout regularly, nitric oxide supplements are something you’ll want to take fairly often. Because of that, you’ll want to consider the price and value of the product(s) you’re considering. Don’t just look at the price alone, as you will want to take into account the included ingredients (and dosages), the number of servings per package, and the brand quality.


Now that you have learned all about nitric oxide benefits and looked at the list of most effective nitric oxide supplements, we hope that you feel prepared to make a purchase and start on your path towards your fitness goals.

If you are curious about other supplements, remember to check out the rest of our site – we have guides like this one on nearly every type of supplement out there. Also, don’t hesitate to ask if you have any questions.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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