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Best SAM-e Supplements – Top 10 Brands Reviewed for 2019

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Recommend a Supplement

In order to help you find a good product, we’ve researched & narrowed down the best SAM-e supplements on the market right now.

Top 10 SAM-e Products Compared

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1. We Like Vitamins Best Value SAM-e

We Like Vitamins Best Value Sam E

We Like Vitamins Best Value SAM-e provides 90 capsules at 500mg strength.


  • Provides 500mg SAM-E per serving
  • Gluten-free
  • Lactose-free
  • Soy-free
  • Contains filler

Who Makes It?

We Like Vitamins is an American-based company. Its nutritional supplements are manufactured following rigorous GMP standards to maintain consistency and quality control.

Bottom Line

These are good SAM-e pills if you’ve been taking the supplement for a while and you want to increase the strength of your dose.

Where to Get It

2. Doctor’s Best SAM-e 400

Doctors Best Sam E 400

Doctor’s Best SAM-e is one of the most effective SAMe supplements on the market. It provides 400mg of SAM-e per serving, making it a potent option and the price is very reasonable. This supplement is available in a 30 count or a 60 count.


  • 400mg of SAM-e per serving
  • Suitable for vegans and vegetarians
  • Contains no common allergens
  • Soy-free
  • Enterically coated

Who Makes It?

This supplement is made by Doctor’s Best Vitamins, a company that was founded by physicians in 1990. This science-based nutritional supplement manufacturer offers over 200 products made with branded ingredients, all of which are rigorously tested and made in cGMP-certified manufacturing facilities.

Bottom Line

This is a powerful SAMe supplement and one of the best offered. If you’re looking for something with high potency, look no further.

Where to Get It

3. Nature Made SAM-e Complete

Nature Made Sam E Complete

Nature Made SAM-e Complete is a strong SAMe supplement that provides 400mg of SAM-e per serving. The bottle contains 36 tablets.


  • Provides 400mg per serving
  • Guaranteed potency and purity
  • Very good price
  • Contains fillers
  • Contains artificial color

Who Makes It?

This SAMe supplement is made by Nature Made, a company that has maintained a reputation for quality for more than 20 years. They take a science-based approach and support public studies and participate in clinical trials. The company produces more than 150 kinds of supplements.

Bottom Line

This product is a good potency. It’s made by a reputable company and is an affordable option.

Where to Get It

4. Source Naturals Double Strength SAM-e

Source Naturals Double Strength SAMe

Source Naturals Double Strength SAM-e provides 400mg of SAMe per serving. The bottle contains 30 pills.


  • 400mg per serving
  • Double strength
  • Tablets in blister packs
  • Enterically coated

Who Makes It?

Source Naturals was founded in 1982. Their aim is to help people understand how their body functions and how to achieve a healthy balance.

Bottom Line

If you’re looking for a good SAM-e supplement with a high dose, this product offers good value for money.

Where to Get It

5. Now Foods SAM-e

Now Foods Sam E

Now Foods SAM-e provides 200mg of SAMe per serving. It also contains vitamins B-12, B-6, and folate. It’s made from a well-known company and is offered at a very affordable price. It’s available with a 30 count or a 60 count.


  • Provides 200mg of SAM-e per serving
  • Contains vitamins B-12, B-6 and folate
  • Enterically coated
  • Does not contain common allergens
  • Contains fillers

Who Makes It?

It is made by NOW, a company that has been a leader in the nutritional supplement industry since 1968. NOW Foods has received a number of prestigious awards including the 2018 Taste for Life Essentials Award and the 2018 Better Nutrition Best of Natural Beauty Award.

Bottom Line

This is a great choice if you’re just starting out with a SAMe supplement because you can increase the dose gradually without it upsetting your stomach. The addition of vitamins B-12, B-6 and folate also may help to facilitate maximum absorption.

Where to Get It

6. Jarrow Formulas SAM-e

Jarrow Formulas Sam E

Jarrow Formulas SAM-e provides 200mg of SAMe per serving. The bottle has 60 tablets.


  • 200mg of SAM-e per serving
  • Enterically coated
  • 68-80% active form
  • Made naturally by fermentation
  • Individually blister-packed

Who Makes It?

Jarrow Formulas is based in Los Angeles, California. It was founded in 1977. It markets its nutritional products throughout the U.S., Mexico, and Canada.

Bottom Line

This is a reasonably priced supplement but because of its relatively low dose, it is more suitable to someone just starting out with SAM-e rather than someone who has been taking it regularly.

Where to Get It

7. Pure Encapsulations – SAMe

Pure Encapsulations Same

Pure Encapsulations – SAMe provides 200mg of SAM-e. The bottle contains 60 tablets.


  • 200mg of SAM-e
  • Suitable for vegetarians and vegans
  • Certified gluten-free
  • Contains fillers
  • High price

Who Makes It?

Pure Encapsulations is an American-based company. They are dedicated to making hypoallergenic supplements.

Bottom Line

Considering the light strength of the tablets, this SAM-e supplement is very expensive. It also contains fillers.

Where to Get It

8. aSquared Nutrition Pure SAM-e

Asquared Nutrition Pure Sam E

aSquared Nutrition Pure SAM-e provides 500mg of SAM-e per serving. The bottle contains 90 capsules.


  • 500mg of SAMe per serving
  • Extra strength
  • Not suitable for vegans or vegetarians
  • Contains filler

Who Makes It?

aSquared Nutrition is an American-based nutritional supplement manufacturer. Their facilities are FDA-registered and GMP-compliant.

Bottom Line

This product is great value if you want an extra-strong SAM-e supplement. It’s not suitable for someone who is just starting out with SAM-e.

Where to Get It

9. Mental Refreshment Nutrition SAM-e

Mental Refreshment Nutrition SAM-e

Mental Refreshment Nutrition SAM-e provides 1500mg per serving. The bottle contains 90 capsules.


  • 1500mg of SAMe
  • Not suitable for vegetarians or vegans
  • 100% satisfaction guarantee
  • Made in the USA, strictly Good Manufacturing Practices

Who Makes It?

Mental Refreshment Nutrition produce and retail high-end nutritional supplements. They currently offer a range of over thirty products.

Bottom Line

This supplement is very strong and good value for money. If you’re just starting to take SAM-e the high strength of this supplement may upset your stomach.

Where to Get It

10. Piping Rock Health Products SAM-e


Piping Rock Health Products SAM-e provides 200mg of SAM-e per serving. The bottle contains 60 tablets.


  • 200mg per serving
  • Suitable for vegans and vegetarians
  • Contains filler
  • Contains artificial color

Who Makes It?

Piping Rock Health Products was formed in 2011. Their aim is to manufacture high-quality nutritional supplements that are affordable.

Bottom Line

This supplement is great value for money. Unfortunately, it contains some fillers and artificial colors.

Where to Get It

Frequently Asked Questions About SAM-e Supplements

What is SAM-e?

SAM-e stands for S-adenosyl-L-methionine. It is a compound made naturally in the human body and it helps to trigger the production of hormones and to regulate them, supports a healthy immune system, and helps with the maintenance of cell membranes. It also plays a role in the production and breakdown of chemicals in the brain.

Though it is primarily produced in the liver, it can be found throughout the body.  A synthetic version of SAMe is available as a dietary supplement. It may be taken orally, via muscular injection, or intravenously. SAM-e is not available from food. Having a vitamin B12 or folate deficiency can reduce the levels of SAM-e in your body.

What Are the Uses & Benefits of SAM-e?

SAMe benefits are numerous, and it has been studied extensively as a potential option to address a number of different health issues. With that said, it’s good to keep in mind that most studies have looked at intravenous applications of SAMe, so it’s unclear if oral supplement forms may be as effective. Some of the potential SAMe benefits that have been looked at include:

  • Osteoarthritis: SAM-e may be effective for alleviating joint pain and inflammation associated with osteoarthritis. It may also stimulate cartilage repair. In a study published in BioMed Central Musculoskeletal Disorders, SAMe supplements were shown to be just as effective, over 4-12 weeks, as nonsteroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis of the spine, hip or knee.
  • Fibromyalgia: This is a chronic disorder that affects joints, bones, and muscles. It causes widespread pain and fatigue and can also lead to depression. In a Danish study conducted in 1991, fibromyalgia patients who were given 800mg of SAM-e each day experienced less fatigue, pain and morning stiffness as well as improved mood, after 6 weeks of use.
  • Liver disease: People who are suffering from liver disease are typically unable to synthesize SAMe. SAM-e is used throughout Russia, China, Eastern Europe, and Southern Asia as a therapy for liver disease. Though pre-clinical evidence exists that SAMe plays an important role in liver health, clinical research is needed to assess how effective it is for liver disease.

How Do I Take SAM-e?

If you wish to supplement your diet with an oral dose of SAM-e, the University of Maryland Medical Center recommends beginning with a low SAMe dosage, such as 200mg per day. Increasing the SAMe supplement dosage gradually prevents upset stomach.

It is also important to remember that many clinical studies of SAM-e have tested injectable, rather than oral forms. Because of this, it is not always clear whether taking an oral supplement is as effective as an intramuscular injection.

Many healthcare practitioners recommend taking folic acid, B12 and methionine with SAMe to increase absorption.

Generally speaking, it’s advisable to simply take the dosage recommended by the product you are using. For more customized dosage recommendations, you can speak to your doctor.

Are There Any Side Effects of SAM-e?

Side effects may include nausea, insomnia, restlessness, sweating, palpitations, and dizziness. Some of these symptoms can be avoided by not taking SAMe at night. Large doses may cause abnormally elevated mood. For this reason, people suffering from bipolar disorder should avoid taking SAM-e as it may trigger or worsen manic episodes.

Pregnant and breastfeeding women should not take a SAM-e supplement because safety for pregnant women is unclear at this time.

You should not take SAM-e if you are being treated with the following medications:

  • Pentazocine (Talwin)
  • Dextromethorphan (Robitussin DM)
  • Tramadol (Ultram)
  • Meperidine (Demerol)

Because SAMe may interact with antidepressant medications, if taken together they may cause accelerated heart rate, anxiety, restlessness, headache, or serotonin syndrome. You should consult your physician if you are taking antidepressants and considering taking SAMe.

You should avoid SAMe if you suffer from diabetes, as it may lower blood sugar levels and increase the effect of diabetes medications. Speak to your doctor if you have concerns.

How Do I Pick a Good SAM-e Product?

The quality of SAM-e can vary significantly between different brands. When choosing a SAM-e supplement you should look for SAMe pills that have high potency and do not contain artificial colors or preservatives. The best SAMe pills are also free of unnecessary fillers and made by large, reputable companies.

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1 Comment

  1. Rob on September 9, 2019 at 8:34 am

    Good info
    But one thing I learned …
    Sam-e is unstable and “bottle” form is not exactly good quality, compared to pulse pack.

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