Vitamins Vitamin B6

Best Vitamin B6 Supplements – Top 10 Brands for 2022

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In order to help you find a good product, we’ve researched & narrowed down the best vitamin B6 supplements on the market right now.

Top 10 Vitamin B6 Products Compared

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1. NOW Foods Vitamin B6

Now Foods Vitamin B6

NOW Foods Vitamin B6 is an effective vitamin B6 supplement that is affordable and produced by one of the most reputable natural supplement brands.

What’s In It?

  • One Serving (1 Capsule) contains
    • 100 mg Vitamin B-6 (from Pyridoxine HCl)

Who Makes It?

NOW Foods is a natural supplement brand that was founded in 1968. The company holds numerous awards for its top-rated formulas, sustainable and ethical business practices. They are committed to providing consumers with high quality, natural supplements.

Where to Get It

2. Nature’s Bounty Vitamin B6


Nature’s Bounty Vitamin B6 is an extremely affordable vitamin B6 tablet that is formulated with pyridoxine HCL and suitable for vegetarians.

What’s In It?

  • One Serving (1 Tablet) contains
    • 100 mg Vitamin B-6 (as Pyridoxine Hydrochloride)

Who Makes It?

Nature’s Bounty is the flagship brand of Nature’s Bounty Co., a natural supplement producer founded in 1971. They specialize in natural health products, and all their supplements are produced in GMP certified facilities.

Where to Get It

3. Nature’s Way Vitamin B6

Natures Way Vitamin B6

Nature’s Way Vitamin B6 provides you with a good vitamin B6 dosage at a very affordable price and is gluten-free.

What’s In It?

  • One Serving (1 Capsule) contains
    • 50 mg Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)

Who Makes It?

Nature’s Way is a family of supplement brands founded in 1969 that are reliable and TRU-ID certified transparent. Some of their most popular supplement types include vitamins, minerals, herbs, probiotics, and coconut oils. They are proud partners of the non-GMO project, and all their products are produced in GMP certified facilities.

Where to Get It

4. Nature Made Vitamin B6

Nature Made Vitamin B6

Nature Made Vitamin B6 is a #1 pharmacist recommended vitamin B6 tablet that is affordable and free from artificial colors, flavors, and preservatives; as well gluten. It also contains calcium.

What’s In It?

  • One Serving (1 Tablet) contains
    • 100 mg Vitamin B6 (as Pyridoxine Hydrochloride)
    • 30 mg Calcium (as Calcium Carbonate)

Who Makes It?

Nature Made is a top supplement brand that has been producing quality supplements for over 40 years. Their products are verified by United States Pharmacopeia (USP), which means they meet stringent quality control measures for purity and potency. The brand is a #1 pharmacist recommended vitamin and supplement brand.

Where to Get It

5. Source Naturals Vitamin B6

Source Naturals Vitamin B6

Source Naturals Vitamin B6 is a vitamin B6 tablet free from yeast, dairy, egg, gluten, corn, soy or wheat. It also has no artificial colors, preservatives, flavors or fragrances

What’s In It?

  • One Serving (1 Tablet) contains
    • 500 mg Vitamin B6 (as Pyridoxine HCl)

Who Makes It?

Source Naturals is a well-known brand specializing in nutraceutical and herbal supplements. It was founded in 1982 with the first supplement to combine herbs, nutraceuticals and other nutrients in one supplement.

Where to Get It

6. Solaray Vitamin B-6


Solaray Vitamin B6 is a part fast-acting, part time-released vitamin B6 supplement. The first stage rapidly releases while the second stage releases over a period of time. Formulated with pyridoxine HCl in vegetable capsules, this two-stage supplement is an effective vitamin B6 product.

What’s In It?

  • One Serving (1 Vegetarian Capsule) contains
    • 100 mg Vitamin B6 (as Pyridoxine HCl)

Who Makes It?

Solaray is a nutraceutical brand that was founded in 1973 and acquired in 1993. They carry over 1,000 health supplement products.

Where to Get It

7. Life Extension Vitamin B6

Life Extension Vitamin B6

Life Extension Vitamin B6 is free from milk, egg, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, gluten, and corn. It is also suitable for vegetarians.

What’s In It?

  • One Serving (1 Vegetarian Capsule) contains
    • 250 mg Vitamin B6 (pyridoxine HCl)

Who Makes It?

Life Extension is a vitamin and supplement producer that focuses on quality, purity, and potency. Founded in the early 80s, their products are generally focused on improving life spans.

Where to Get It

8. BulkSupplements Pure Vitamin B6

Bulksupplements Pure Vitamin B6

BulkSupplements Pure Vitamin B6 is a pure pyridoxine HCL powder that can be purchased in bulk quantities. This is a pretty good choice of vitamin B6 for athletes because it can be easily added to a good protein shake.

What’s In It?

  • Powdered form so you can customize serving size
  • Pure Pyridoxine HCL Powder (source of Vitamin B6)

Who Makes It?

BulkSupplements is a supplement ingredient supplier that sells over 200 different ingredients to both customers and supplement producers. Their products are available in sizes from grams to metric tons.

Where to Get It

9. Solgar Vitamin B6

Solgar Vitamin B6

Solgar Vitamin B6 is one of the best choices of b6 for vegans and is non-GMO & certified gluten-free. It is also free of wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives and colors. To top it off, it’s kosher and halal!

What’s In It?

  • One Serving (1 Vegetable Capsule) contains
    • 100 mg Vitamin B6 (as pyridoxine HCl)

Who Makes It?

Solgar is a well-known supplement producer that was founded in 1947. They provide over 450 advanced nutritional supplements to consumers worldwide.

Where to Get It

10. BlueBonnet Vitamin B-6

Bluebonnet Vitamin B 6

BlueBonnet Vitamin B6 is a vegan vitamin B6 that is free from gluten, dairy and soy. It is also non-GMO, kosher certified and contains no milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans.

What’s In It?

  • One Serving (1 Capsule) contains
    • 100 mg Vitamin B6 (as pyridoxine HCl)

Who Makes It?

BlueBonnet Nutrition is a natural health supplement brand that has been in the industry for over 26 years. Their products are whole food, farm-to-table and USDA-certified organic.

Where to Get It

Frequently Asked Questions About Vitamin B6 Supplements

What Is Vitamin B6?

Protein is an important macronutrient that helps your body build tissues for purposes of healing, growing and gaining muscle. It is also beneficial to those trying to lose weight – it promotes satiety, and takes longer to digest than carbohydrates and fats.

However, it takes longer to digest because it is harder to digest. The digestion of protein requires an important metabolic vitamin known as vitamin B6 or pyridoxine.

Vitamin B6, also known as pyridoxine, is one of 8 different essential B vitamins that play an important role in the function of the metabolism. All B vitamins help to metabolize carbohydrates into usable energy for the body in the form of glucose, but vitamin B6 specifically has the ability to help neurotransmitters and metabolize proteins and amino acids.

Some foods that include vitamin B6 are:

  • Chicken
  • Turkey
  • Tuna
  • Salmon
  • Milk
  • Cheese
  • Lentils
  • Beans
  • Spinach
  • Carrots
  • Brown rice
  • Bananas
  • Whole grains

Deficiency in B6 is not common in developed countries, however, it can still occur in those who do not eat balanced diets, are dependent on alcohol, have malabsorption issues or take medications that may inhibit absorption.

The symptoms of deficiency include depression and confusion, cracked lips, swollen tongue, inflammation, and weakened immune function.

The best supplement sources of vitamin b6 can be found in various supplemental forms, including capsules, tablets, chewable, liquid drops, multivitamins and more.

What Are the Uses & Benefits of Vitamin B6?

Vitamin B6 can help to improve many aspects of health. It supports the body’s ability to digest proteins and obtain energy from foods.

Alongside this, they also help to support mental health by supporting neurotransmitter production.

All the B vitamins, including B6, play a number of important roles in the body. Some of the most important roles of B6 specifically include:

  • Brain function: Vitamin B6 plays a role in the health and function of our brains. It is thought that a deficiency in the vitamin may contribute to cognitive impairment and even neurodegenerative diseases like Alzheimer’s. B6 has been shown to regulate homocysteine levels, which if left unchecked can contribute to damage in the central nervous system. B6 may also contribute to the production of serotonin and norepinephrine, two very important hormones for mood and concentration. With all that said, vitamin B6 deficiency is rare, and it’s unclear whether taking b6 supplements is beneficial for those who already consume enough in their diet.
  • Blood vessels: Vitamin B6 may help to reduce homocysteine levels, which allows the body to properly heal damaged blood vessels. A deficiency in B6 can cause abnormally high homocysteine levels, which can damage blood vessels and increase your risk of stroke and heart attack.
  • Mood: Getting enough vitamin B6 in your diet may help to reduce stress, improve your mood and reduce the risk of mood disorders. This is because B6 plays a role in the production of serotonin and other hormones in the brain. Certain brain diseases and conditions, such as anxiety and depression, that develop as a result of neurotransmitter function deficiencies may be improved by vitamin B6.
  • Eye health: Several of the B vitamins, namely B6 and folate, have a close relationship with eye health. Some b-vitamin deficiencies may lead to an increased risk of eye disorders including age-related macular degeneration. Thus, it’s thought that increasing B vitamin intake may be beneficial for eye health.
  • PMS: There is evidence to suggest that an increase in vitamin B6 intake may help to reduce the symptoms of premenstrual syndrome (PMS) in women. B6 can have positive effects on the neurotransmitters responsible for pain management, so it can potentially help reduce some of the painful symptoms associated with PMS.
  • Pregnancy: Some studies have shown a reduction in nausea and “morning sickness” in pregnant women who take vitamin B6 or a B-vitamin complex.

Vitamin B6 plays many other roles in the body. If you are deficient in the nutrient, taking supplemental B6 may offer a host of benefits beyond what is described here. However, most people get enough B6 from the diet alone, so for many taking supplemental B6 is not necessary.

By facilitating protein digestion and absorption, vitamin B6 supplements help to improve muscle growth and weight loss for athletes and those trying to shed extra pounds. They also help serotonin levels, which have beneficial effects on the brain and central nervous system.

Who Can Benefit from Vitamin B6?

  • Athletes – Athletes who consume lots of protein for either bulking up or slimming down should take vitamin B6 – especially if they consume a lot of their protein from protein powder or plant-based proteins. Many types of meat contain certain amounts of vitamin B6 that help to support their digestion, but plant sources of proteins have less bioavailable B6, and protein powders may not contain B6 at all. To ensure proper protein digestion and absorption to achieve athletic goals desired, try a vitamin B6 supplement.
  • Those with Anxiety – B6 supplements can help to support mental health by supporting and regulating healthy hormone production. Vitamin B6 can also help to support the production of serotonin, a neurotransmitter that plays an important role in regulating your mood. This important neurotransmitter helps to regulate anxiety, prevent depression and promote happiness.
  • Those with Cardiovascular Health Issues – There is moderate clinical evidence that suggests vitamin B6 may help heart disease and high blood pressure. One of the ways in which vitamin B6 may help support heart health is by lowering levels of homocysteine (an amino acid) in the bloodstream. Homocysteine is associated with blood clotting disorders, heart disease, heart attack, and even stroke.

How Do I Take Vitamin B6?

Vitamin B6 is a water-soluble supplement, which means it does not have to be taken with food or a source of fat for proper absorption.

They should be taken daily in proper vitamin B6 dosages for effects to be notable. B vitamins should be taken in the morning or middle of the day, because taking them at night may interfere with sleep.

All B vitamins can be found in the form of a B-complex supplement, which stacks all essential B vitamins together for improved metabolic benefits. However, you can stack certain individual B vitamins together to tailor benefits for a particular purpose.

Vitamin B6 can also be stacked with other supplements for enhanced health benefits. Here are a couple of good ways to stack vitamin b6:

  • Vitamin B6, B12, and Folic Acid – Vitamin B6, B12 and folic acid make a good vitamin B6 stack for cardiovascular health. Many studies have found that this combination is most effective for reducing homocysteine levels in the blood, reducing the risk of cardiovascular issues.
  • Vitamin B6 and Magnesium – Vitamin B6 and magnesium have been studied for potential neurological benefits for those with autism. Studies have shown promising results.

Are There Any Side Effects of Vitamin B6?

Vitamin B6 is generally well-tolerated, which means most people do not experience negative side effects from them.

However, some people may experience side effects such as nausea, vomiting, loss of appetite, sleepiness and more. Check with your doctor if you have concerns.

How Do I Pick a Good Vitamin B6 Product?

The highest quality vitamin B6 supplements are generally formulated with B6 in the form of pyridoxine HCl, which is well absorbed by the body. Tablets and capsules tend to be the best forms for absorption and ease of supplementation.

Ensure that your product is produced by a reputable brand in a GMP certified facility, and make sure that your supplement does not contain any unnamed ingredients.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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