Mood 5-HTP

Best 5-HTP Supplements – Top 10 Brands for 2022

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Find out how this list was made

To help you find a good product, we’ve researched & narrowed down the best 5-HTP supplements on the market right now.

Top 10 5-HTP Products Compared

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1. Natrol 5-HTP

Natrol 5 Htp

Natrol 5-HTP is a popular product offering 200mg of 5-HTP per serving. It’s one of the best-selling supplements in its category, and for good reason: it’s affordable, accessible, and effective. This product uses a unique time-release formula to help deliver a slow-and-steady stream of 5-HTP to your body. This can help prolong the beneficial effects of 5-HTP, providing a continual release for up to 10 hours.


  • 200mg 5-HTP per serving
  • Time-release formula
  • Provides benefits for up to 10 hours
  • Popular and best-selling (#1 5-HTP brand)
  • Affordable & great value

What’s In It?

  • 200mg 5-HTP
  • 55mg calcium

Who Makes It?

This product is made by Natrol, a large supplement manufacturer headquartered in Los Angeles, California. Since it was founded in 1980, Natrol has made a name for itself by producing cutting-edge, highly effective supplements across broad categories. They consistently produce high-quality products, and their size allows them to keep pricing competitive and affordable for consumers.

Bottom Line: Overall, this is perhaps the go-to 5-HTP supplement out there today because it has consistently well-rated reviews, and it’s made by a company that is well respected and stands behind their products. If you’re looking for an effective 5-HTP source, this is an excellent choice.

2. Nutrigold 5-HTP Gold

Nutrigold 5 Htp Gold

Nutrigold 5-HTP Gold is a simple and pure 5-HTP supplement containing 100mg of the active ingredient. It’s packaged in vegetarian capsules and is completely free of common allergens and GMOs.


  • 100mg 5-HTP per serving
  • Vegetarian capsules
  • Free of gluten, GMOs, and most common allergens
  • Simple and pure

What’s In It?

  • 100mg 5-HTP

Who Makes It?

This product is made by Nutrigold, a company that aims to be the gold standard for the supplement industry. Based in Utah, USA, Nutrigold is committed to 6 founding principles: transparency, quality, purity, originality, sensitivity, and accountability. By following these guiding principles, Nutrigold consistently produces high-quality herbal supplements and health products.

Bottom Line: Nutrigold 5-HTP Gold is a high-quality product from a great company. It contains the standard 100mg dose and is made without unnecessary fillers or additives. It’s a great product, but a bit on the expensive side.

3. Doctor’s Best 5-HTP Enhanced


Doctor’s Best 5-HTP Enhanced contains 100mg of 5-HTP. and vitamins B6 and C, which are added to help the absorption of the active ingredient.


  • 100mg 5-HTP
  • Added vitamin B6 and vitamin C
  • Made by a good company

What’s In It?

  • 100mg 5-HTP
  • 200mg vitamin C
  • 15mg vitamin B6

Who Makes It?

This product is made by Doctor’s Best, a well-known and well-respected supplement manufacturer. Doctor’s Best uses clinical research to develop cutting-edge supplements.

Bottom Line: Overall, this is a good product from a good company. It works well, but it does contain a few additives.

4. NOW Foods 5-HTP

Now Foods 5 Htp

NOW Foods 5-HTP is a top 5-HTP supplement made by a reliable and well-known supplement firm. It contains 100mg of 5-HTP per capsule, which makes it easy to customize your dose to your individual needs.


  • 100mg 5-HTP per serving
  • Simple and effective formula
  • Made by one of the largest supplement companies in the world
  • Well reviewed
  • Affordable & great value

What’s In It?

  • 100mg 5-HTP

Who Makes It?

This product is made by NOW Foods, a large-scale health food and supplement manufacturer with operations worldwide. With decades of experience, NOW is a clear leader in the industry, consistently producing high-quality products at very affordable prices. They are also known for having excellent customer service.

Bottom Line: Overall, this is one of the better 5-HTP pills on the market. Its simple formula offers nothing but pure 5-Hydroxytryptophan, and the 100mg dose is perfect for starting low and customizing your dose if needed. And since this is made by NOW Foods, you can trust in the quality and consistency of the product.

5. Thorne Research 5-Hydroxytryptophan

Thorne Research 5 Hydroxytryptophan

Thorne Research 5-Hydroxytryptophan is a pure and effective 5-HTP supplement. It contains 100mg 5-HTP, plus added vitamin B6, which is said to increase the absorption of the supplement. As with all Thorne Research products, the ingredients used in this product are pure and sourced from the finest sources possible.


  • 100mg 5-HTP per serving
  • Added vitamin B6 to increase absorption & efficacy
  • Made by a very good company
  • Affordable & good value

What’s In It?

  • 100mg 5-HTP
  • 8mg vitamin B6 (to increase absorption & efficacy of 5-HTP)

Who Makes It?

This product is made by Thorne Research, a large supplement manufacturer that has been a leader in the industry for more than 30 years. Committed to the pursuit of quality, Thorne consistently works towards the bettering of the health of all its customers.

Bottom Line: Overall, this is a solid 5-HTP product that includes vitamin B6, which is said to increase absorption rates and therefore improve on the benefits of 5-HTP. It’s also affordable, well-reviewed, and made by a very good company with a long reputation for quality.

6. Pure Encapsulations 5-HTP

Pure Encapsulations 5 Htp

Pure Encapsulations 5-HTP is a simple and straightforward supplement that offers a dosage size of 100mg. It is hypoallergenic and made from very simple ingredients.


  • 100mg 5-HTP per serving
  • No fillers or additives
  • Hypoallergenic
  • Made by a great company


  • Expensive

Who Makes It?

This product is made by Pure Encapsulations, a company that focuses on producing pure, simple and effective supplements using high-quality ingredients.

What’s In It?

  • 100mg 5-HTP

Bottom Line: This is a pure and simple option for those looking for 5-HTP. It is a bit on the expensive side, though.

7. Solaray 5-HTP


Solaray 5-HTP offers 50mg of 5-HTP per serving. Although this is a lower dosage than usual, it makes it easy to customize the amount you take.


  • 50mg 5-HTP
  • Made by a good company

What’s In It?

  • 50mg 5-HTP

Who Makes It?

This product is made by Solaray, a division of Nutraceutical. This is a large scale natural supplement manufacturer that is known for quality and consistency and has many best-selling products.

Bottom Line: The dosage is quite small at 50mg, which also makes this product rather expensive for what it offers.

8. Integrative Therapeutics 5-HTP

Integrative Therapeutics 5 Htp

Integrative Therapeutics 5-HTP offers 50mg per serving. The dosage size is relatively low, but they are made by a good company and are well-reviewed.


  • 50mg 5-HTP per serving
  • No fillers or additives
  • Simple formula

What’s In It?

  • 50mg 5-HTP

Who Makes It?

This product is made by Integrative Therapeutics, a mid-sized supplement manufacturer headquartered in Wisconsin. They specialize in supplements to treat gastrointestinal issues, metabolic issues, and more.

Bottom Line: This is a straightforward and simple option. The low dosage combined with the relatively high price means that there are better options, though.

9. Douglas Labs 5-HTP


Douglas Labs 5-HTP is a good supplement containing 50mg of 5-HTP. It’s made by a good company and utilizes a simple formula with no fillers.


  • 50mg 5-HTP per serving
  • No fillers/additives
  • Well reviewed
  • Provide 5-HTP benefits

What’s In It?

  • 50mg 5-HTP

Who Makes It?

This product is made by Douglas Labs, a US-based supplement producer that has been in business since 1955.

Bottom Line: Overall, this is a good product with good reviews, but it’s quite expensive and offers only 50mg per dose.

10. Designs For Health 5-HTP Synergy


Designs for Health 5-HTP Synergy is a good 5-HTP and B6 supplement that offers a combination of ingredients designed to work together.


  • 50mg 5-HTP
  • 10mg vitamin B6

Who Makes It?

This product is made by Designs for Health, a health product company dedicated to putting science first in their product development.

Frequently Asked Questions About 5-HTP Supplements

What is 5-HTP?

5-HTP, formally known as 5-Hydroxytryptophan, is a chemical compound that is typically derived from the seeds of the African-native Griffonia simplicifolia plant. 5-HTP is commonly used to aid a wide variety of sleep and mood disorders, including insomnia, migraine relief, and much more.

It’s available in supplement form, which makes it easy to harness the 5-HTP benefits for better health.

The primary function of 5-HTP is to enhance serotonin production in the brain. Serotonin, a brain chemical vital for the regulation of emotion and mood, is always present in our bodies and brains. But sometimes, an imbalance occurs, which in many cases can lead to the development of a serious health issue.

5-HTP supplements basically act as a precursor to serotonin itself, as 5-HTP is converted into serotonin in the brain. Supplementing with 5-HTP increases serotonin synthesis in the brain and central nervous system, creating a noteworthy increase of serotonin levels present in the body.

Serotonin is a vitally important brain chemical for a large variety of reasons, so many people who may have a serotonin imbalance may potentially benefit from 5-HTP.

What Are the Uses & Benefits of 5-HTP?

5-HTP is an amino acid that’s been studied for a variety of uses. Primary potential 5-HTP benefits include:

  • Depression: 5-HTP acts as a precursor for the biosynthesis of melatonin and serotonin in the brain. Depression is often at least partially caused by an imbalance of brain hormones, particularly serotonin. Thus, some researchers speculate that 5-HTP may be effective for depression – and one study found that it was more effective than a placebo in helping depression symptoms. It’s also thought that 5-HTP may help to boost the effects of antidepressants and SSRIs, with one small study finding a significant increase in the neuroendocrine response to an SSRI when it was combined with 5-HTP. Most studies looking at 5-HTP and depression have been rather small, so researchers warn that more research using larger participant groups is needed. Speak with your doctor before taking 5-HTP.
  • Anxiety: 5-HTP shows some promise in addressing anxiety and panic attacks. One small study with 15 youth participants found that anxiety levels were notably decreased after 3 weeks of 5-HTP supplementation. This effect was attributed to an increase in brain-derived serotonin and neurotrophic factor levels. 5-HTP has also shown efficacy in addressing chronic panic attacks. Lastly, 5-HTP can positively affect GABA receptor agonists in the brain, potentially increasing GABA levels. This can help cultivate a sense of relaxation, and potentially reduce anxiety levels. More research is needed, as many of these trials used a small participant group.
  • Appetite: There is some evidence to suggest that 5-HTP may help to curb appetite. It is thought that increased serotonin levels in the brain may help to curb the craving for carbohydrates, potentially helping people stick to diet plans and lose weight. In one small study, obese participants were given 5-HTP and showed decreased food intake and increased weight loss. This is probably why 5-HTP is sometimes added as an ingredient in fat burning supplements. Again, most of the studies looking at this effect have been quite small, so more research is needed.
  • Sleep: Some evidence suggests that 5-HTP may have a positive effect on sleep quality and duration, particularly for those with sleep disorders. Serotonin has an effect on the circadian rhythm, an important factor in sleep quality, and 5-HTP has been shown to potentially increase serotonin levels. Some believe that the relaxing effects of 5-HTP may also make it easier to get to sleep. More research is needed.

Overall, 5-HTP shows a lot of promise – but it simply hasn’t been studied enough. Larger-scale studies are needed to confirm results and explore other potential uses of 5-HTP.

Who Can Benefit from 5-HTP?

The primary group of people who can benefit from taking 5-HTP supplements is those suffering from anxiety, depression, sleep disorders, eating disorders, and related issues. Anyone with an imbalanced brain chemistry could also benefit.

The groups who will experience the most benefit from effective 5-HTP supplements include:

  • Those with mild to moderate depression – depression affects hundreds of millions of people each year. While each case is different, many people who are depressed are suffering from an imbalance of brain chemistry. 5-HTP supplements are effective at increasing the production of serotonin, the brain chemical most associated with mood, and can, therefore, help to counter the effects of depression. Please note you should absolutely speak with your doctor if you are experiencing depressive symptoms.
  • Those with anxiety – anxiety often goes hand in hand with depression and is also often caused by a brain chemical imbalance. If you suffer from anxiety, you likely know how debilitating and frustrating it can be – but using a 5-HTP product, after speaking with your doctor about it, may help. 5-HTP is commonly used to counter the effects of anxiety and may be useful in treating a variety of related mood disorders and conditions.
  • Those with eating disorders or those on diets – 5-HTP can also be effective for curbing appetite and reducing overeating. This, too, is largely attributed to the supplement’s effects on brain chemistry. 5-HTP’s effect on appetite is one of the most well-documented benefits of 5-HTP, with several clinical trials showing very promising results. 5-HTP can be a valuable addition to your next diet. For those with actual eating disorders, it can also be helpful, but you should discuss treatment options with your doctor.
  • Those with trouble sleeping – if you suffer from insomnia or have trouble getting to sleep, you may benefit from taking good 5-HTP supplements. Many people have reported better, deeper sleep after taking the supplement, as well as noting that less time was required to actually get to sleep.
  • Those suffering from PMS or menopause – women experiencing the symptoms of PMS report feeling reduced symptoms, while older women entering menopause have also reported positive reductions in menopausal symptoms.

As you can see, 5-HTP supplements can show benefits for a wide range of people. And since the compound has relatively few side effects, it’s definitely worth trying out.

How Do I Take 5-HTP?

5-HTP comes in pill form, and there will be detailed instructions on the product packaging. The typical 5-HTP supplement dosage is around 100-300mg, which can be taken at once or split up into smaller doses. Some clinical trials have shown better results from larger quantities.

To take advantage of 5-HTP benefits relating to mood, depression, etc, the supplement can be taken at any time of the day. For its effects on appetite to take hold, it’s best to take 5-HTP with meals. A 5-HTP dose taken shortly before a meal can increase satiety, or the feeling of fullness, making it easier to avoid overeating.

It should be noted that while 5-HTP side effects are generally minimal, the supplement should not be taken with prescription medications administered as antidepressants or SSRIs.

Speak with your doctor if you are on antidepressants or other cognitive prescription drugs.

Are There Any Beneficial 5-HTP Stacks?

5-HTP supplements are quite useful on their own, but in some cases combining them with other supplements can be useful. Building a 5-HTP supplement stack can create some impressive results.

For instance, some people use 5-HTP and melatonin supplements for sleep, or 5-HTP and fish oil for mood & brain chemistry regulation.

Are There Any Side Effects of 5-HTP?

When dosed properly, 5-HTP side effects are minimal. That said, side effects are possible – including nausea and related stomach issues, heartburn, bloating, gas, and a decrease in appetite.

In extreme examples more, serious side effects have occurred, but that’s generally only when very large doses are consumed.

It’s also possible that 5-HTP could interact with certain medications – namely SSRIs and antidepressants. If you are on any pharmaceutical drug for anti-depressive or cognitive purposes, check with your doctor before beginning 5-HTP supplementation.

How Do I Pick a Good 5-HTP Product?

There are a lot of good 5-HTP supplements out there, which can sometimes make it difficult to choose the best option for you.

Here are some factors you should pay attention to when buying one.

Included ingredients – take a look at what ingredients are included, and at what quantities. 100-200mg of 5-HTP per serving is standard. Some products also use vitamin B6, which may help to increase the efficacy of 5-HTP.

Value – take a look at the price of the product on a per-serving basis. You don’t necessarily need to find the cheapest possible option, but the price should be considered.

Brand reputation – who makes the product, and what is their reputation? Buying from a good brand is extremely important, which is why we only list products from reputable companies.

How Did We Pick These Supplements?

Our core value at Top10Supps is transparency which is why we are open about how we pick the supplements that you just saw. You can read more about our supplement ranking methodology here.

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