Guides 11 Best Supplements for Anxiety Relief

11 Best Supplements for Anxiety Relief

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Although some degree of anxiety in life is normal, like before a big test or a first date, for some people it can completely take over their lives; making once easy tasks, super difficult.

Anxiety can become so extreme that it’s been classified as a mental health disorder.

According to diagnostic interview data via the National Comorbidity Study Replication (NCS-R), this disorder affects 40 million people in the United States with 31% of people experiencing some form at some point in their lives. It also occurs more often in women than in men (1).

Types of Anxiety

Anxiety disorder is an umbrella term for several different disorders.

These disorders include:

  • generalized anxiety disorder
  • post-traumatic stress disorder (PTSD)
  • social anxiety
  • panic disorder
  • separation anxiety
  • specific phobias
  • and obsessive-compulsive disorder

These conditions are all characterized by an inability to function, due to:

  • excessive nervousness
  • worry
  • fear
  • apprehension
  • restlessness

It can permeate every aspect of your life and result in physical symptoms like lack of sleep, elevated blood pressure, or weight gain (2).

But, can you do anything about it?

Treating severe anxiety may require a combination of medical intervention and psychotherapy. But, anxiety symptoms can also benefit from lifestyle changes including natural stress management, exercise, diet, relaxation techniques, and various natural supplements.

Here’s a quick visual of the ones we’ll cover in this article. Read on to find out more about each one.

Best Supplements For Anxiety Infographic From Top10supps

ⓘ We strongly recommend that you consult with your healthcare provider before taking any supplements to ensure there are no contraindications and that they are right for you. This information is not intended to replace professional advice or meant to be used to prevent, diagnose, or treat any disease or illness.

11 Natural Supplements for Anxiety

Here are a few study-backed supplements to help manage anxiety and panic attacks.


Ashwagandha Extract

Sometimes called Indian Ginseng, it is an adaptogenic herb used for centuries in Ayurvedic medicine. Adaptogens are herbs that help mitigate the effects of stress and anxiety in the body.

But, ashwagandha has other benefits beyond just promoting relaxation, it can also (3):

  • boost the immune system
  • improve memory and concentration
  • support brain health
  • promote heart health

How does ashwagandha fight anxiety?

A 2012 study evaluated the impact of ashwagandha supplements on 64 subjects with chronic stress and anxiety.

The researchers measured cortisol levels and assessed subjects’ stress levels with various self-assessment questionnaires. Subjects then received either 300 mg ashwagandha twice a day or a placebo, for 60 days.

Those given the ashwagandha reported a significant reduction in stress when compared to a placebo. Even cortisol levels, an indication of stress levels, were lowered (4).

Other studies have shown similar results that ashwagandha can significantly improve the effects of stress (5).

How to Take Ashwagandha

The recommended dose of ashwagandha for stress and anxiety management is 600-900 mg a day. This is usually divided into two doses.

There are no major side effects that have been reported with taking ashwagandha, although some people report sleepiness and headaches.

The most potent ashwagandha is made solely from the roots of the plant. The leaves, which are sometimes included, may dilute the efficacy and do not contain as much of the active ingredient called withanolides.

On that note, look for a product that contains at least 2-5% withanolides.

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Sources Of L Theanine

L-theanine is an amino acid found in green tea; it is the reason a cup of tea can be so relaxing. This is because it increases the production of alpha brain waves which have been linked to a feeling of “alert relaxation.”

How does l-theanine fight anxiety?

A 2011 study evaluated the effects of l-theanine on anxiety symptoms of patients with schizophrenia.

Sixty patients were given either 400 mg/day of l-theanine or a placebo, for 8 weeks.

During the study, they were evaluated using various psychological scales, for various markers, including:

  • anxiety
  • general functioning
  • side effects
  • and quality of life

Those who received l-theanine supplementation were found to have a significant reduction of anxiety and general psychopathology during the study period.

Researchers concluded that l-theanine may be a safe and viable option for treating anxiety in people with other psychiatric conditions (6).

How to Take L-theanine

Since green tea is high in l-theanine, a daily cup of tea is a great way to tap into its benefits. The alert, yet relaxed effects of l-theanine are boosted by a little bit of caffeine.

If caffeine makes you even more anxious, then an l-theanine supplement may be a better way to go.

Though there is no specific recommended dose for l-theanine, most supplements contain around 200 mg.

There have been no reported negative side effects from taking l-theanine, likely because it is an amino acid and will not build up to toxic levels in the body.

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B-Complex Vitamins

Sources Of B Vitamins

B-complex, sometimes called B-stress complex, is a combination of eight B-vitamins:

  • thiamine
  • riboflavin
  • niacin
  • pantothenic acid
  • B6
  • biotin
  • folic acid
  • and B12

All of these vitamins play a role in maintaining a healthy nervous system, helping you stay calm.

How do b-complex vitamins fight anxiety?

A 2012 study evaluated the impact of B-complex supplements on symptoms of depression and anxiety in 60 adults.

Subjects were given the Beck Depression and Anxiety Inventory to assess symptoms and were then given either a B-complex supplement or a placebo, for 60 days.

Those who received the supplement demonstrated significant improvements on the depression and anxiety scale. They also reported increased vitality, well-being, and improved social functioning (7).

How to Take B-complex

Most supplemental dosages of vitamin b-complex range from 300-500 mg per day.

B-vitamins are water-soluble, so there is no major concern for toxicity at normal levels.

If you take a regular multivitamin (men’s or women’s), you probably don’t need an additional B-complex supplement because your body will just excrete what it doesn’t need.

B-vitamins are also widely found in many foods, so a balanced diet including lean protein, whole grains, and green vegetables will also provide adequate amounts.

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Vitamin D

Sources Of Vitamin D

Vitamin D is a fat-soluble vitamin that the body can make on its own from sun exposure. It helps maintain strong bones, by helping with calcium absorption.

It has also been found to:

  • help maintain a healthy weight
  • boost immune function
  • and play a role in managing depression and anxiety

Vitamin D deficiency is extremely common due to lack of proper sun exposure, particularly for people who live in colder climates or those with darker skin. Elderly people also have difficulty converting sunlight into vitamin D.

To make matters worse, this vitamin is not readily found in many foods. It is only found in small quantities in foods such as fatty fish and fortified milk.

How does vitamin D fight anxiety?

A 2015 study found that people with anxiety tend to also have lower levels of vitamin D (8).

At this time there have not been any studies that have found that a vitamin D supplement will treat anxiety symptoms only that there is a connection between low levels and anxiety symptoms.

Further research is needed to solidify the hypothesis that vitamin D is a viable or effective anxiety treatment option.

How to Take Vitamin D

The recommended daily allowance for vitamin D is 400 IU for most adults (9). But, many experts argue that this is too low due to how wide-spread deficiency is for this vitamin.

Many supplements can be found in doses of 1000 IU or above, which may be appropriate if you live in a colder climate or have darker skin.

The best way to know exactly how much vitamin D you need is to have a blood test. If your levels are severely low, your doctor may prescribe a high-dose supplement for a few months to get your levels back to normal.

When choosing between options, it’s recommended to go with vitamin D3, as it is better used by the body than vitamin D2.

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Sources Of Magnesium

Magnesium is frequently called the “relaxation mineral” as it is critical for muscle and nerve function. It helps maintain healthy blood pressure and a normal heart rate.

Many people are not getting enough magnesium due to poor quality diets. Magnesium is found in whole grains and green leafy vegetables.

Too much stress, alcohol, and coffee also deplete magnesium, making deficiency worse.

How does magnesium fight anxiety?

A deficiency in magnesium can increase anxiety and lead to difficulty with relaxation.

A 2012 animal study found that magnesium deficiency caused anxiety symptoms and HPA-axis dysregulation. The HPA-axis is responsible for how our nervous system reacts (10).

Another study conducted in 2008, found a connection between diets low in magnesium and an increase in depression and anxiety (11).

How to Take Magnesium

Magnesium supplements can be used to help promote sleep and relaxation at bedtime.

They are generally safe but have been known to cause digestive problems.

Supplemental magnesium causes water to rush into the digestive tract, which can lead to diarrhea. This is great for those who struggle with constipation, but not so much for those who do not!

The upper limit for magnesium supplements is 350 mg/day; so aim to stay under that for a supplement.

Magnesium can also be absorbed through the skin without the digestive side effects. For anxiety management, consider an Epsom salt bath or a magnesium lotion before bed to promote a restful night’s sleep.

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Sources Of Gaba

Gamma-aminobutyric acid (GABA) is a neurotransmitter and amino acid. GABA has been called a “natural valium” due to its ability to reduce stress, anxiety, and promote sleep.

It is the reason why alcohol and sleep aids promote relaxation and sleep, they both increase GABA in the brain, but obviously not without side effects. Alcohol may make anxiety worse.

GABA also increases with yoga, meditation, and exercise, which are healthier ways to get a boost for your mood.

How does GABA fight anxiety?

People with depression or anxiety are more likely to have low levels of GABA (12, 13).

There isn’t enough conclusive evidence to know if GABA supplements might be an effective treatment for anxiety just yet. But, a 2016 study found that kava kava helped increase GABA receptors in the brain and helped manage anxiety (14).

This suggests the solution may not be taking GABA supplements directly but taking other nutrients to help increase GABA. But as mentioned, more conclusive evidence is needed to say for certain.

How to Take GABA

Research on GABA supplements is preliminary at this time. Dosages used in clinical trials vary from 3 to 5 grams a day, but it is not clear if this is in-fact an ideal dosage.

Most supplements come in 500-750 mg doses.

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Sources Of 5 Htp

5-hydroxytryptophan (5-HTP) is another neurotransmitter that is required to make, the so-called “feel-good hormone,” serotonin. The body is actually able to make 5-HTP on its own from the amino acid tryptophan, but sometimes has trouble converting it all the way to serotonin.

How does 5-HTP fight anxiety?

The research on the effectiveness of using 5-HTP for balancing serotonin levels is mixed and limited.

Some studies claim that supplements can help significantly improve symptoms, but frequently these studies use 5-HTP with other treatments or medications making it hard to figure out what exactly is improving the symptoms (15).

But, some animal studies are promising, showing that 5-HTP can decrease symptoms of anxiety (16).

How to Take 5-HTP

Firstly, the safety of 5-HTP has not been measured long-term. There is some concern that taking 5-HTP for an extended period of time can deplete other neurotransmitters like dopamine and epinephrine (17).

In the short-term, 5-HTP may help relieve anxiety symptoms.

Dosages range from 100-300 mg per day, usually divided up into 100 mg three times a day.

5-HTP might be helpful at bedtime because serotonin helps boost melatonin production, leading to a restful night’s sleep.

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Chamomile Extract

Chamomile is widely known for its medicinal properties and ability to promote relaxation and healing.

There are two main types of chamomile, German and Roman.

The benefits come from plant compounds called terpenoids and flavonoids. These are antioxidants that lower oxidative stress, which can negatively impact the brain (18).

How does chamomile fight anxiety?

A 2016 study evaluated the effects of chamomile on 179 patients with generalized anxiety disorder. Participants were given 1,500 mg of chamomile or a placebo, for 38 weeks.

Those who received the chamomile supplement experienced significantly fewer anxiety symptoms lost weight and had an overall lower blood pressure during the study period (19).

How to Take Chamomile

Chamomile is most commonly enjoyed as tea and can be extremely relaxing as part of a pre-bedtime routine. But, it is also available as a dietary supplement.

The supplement form usually contains 300-500 mg of chamomile.

Although it is generally considered safe, it can cause allergic reactions in people who happen to be allergic to this family of plants.

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Valerian Root

Valerian Root Extract

Valerian is a well-known herb that promotes sleep and relaxation. It may also be an effective treatment for anxiety.

How does valerian fight anxiety?

A 2015 study evaluated the effects of valerian root on a stressful procedure called hysterosalpingography.

Sixty-four women who were undergoing the procedure were given 1,500 mg of valerian or a placebo, 90 minutes before undergoing the procedure.

Those who received the supplement reported significantly less anxiety during the procedure than those who got the placebo (20).

Although the anxiety in this study was acute and related to a specific stressful event, valerian may be useful for managing more generalized anxiety as well.

How to Take Valerian

The average dose of valerian is around 500 mg.

Long-term evidence of its safety is lacking, but no major harmful side effects have been reported either.

It is probably best not to take valerian for more than a few weeks at a time. Side effects may include drowsiness, dizziness, and headaches.

Consider taking it in the evening at home so you know how you will react.

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Rhodiola Rosea Extracts

Rhodiola Rosea is an herb that has been used for centuries for its medicinal properties. It, too, is an adaptogen, like ashwagandha.

It is thought to help decrease stress, relieve symptoms of depression, and improve fatigue. It may also help improve exercise performance.

How does Rhodiola fight anxiety?

A 2015 study evaluated the impact of Rhodiola on anxiety, stress, and other mood-related symptoms.

Eighty participants were given either 200 mg of Rhodiola twice a day or no treatment.

After 14 days, subjects reported a significant reduction in anxiety, anger, stress, depression, and confusion (21).

How to Take Rhodiola

Rhodiola is found in either capsule, liquid, or tea forms. Dosages in supplements range from 100 to 700 mg daily. There have been no major side effects reported with Rhodiola, although some report feeling jittery.

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Sources Of S Acetyl Glutathione

Glutathione is one of the most powerful antioxidants in the body, helping lower inflammation and neutralize oxidative stress. Its antioxidant power indicates that it may be able to decrease the risk of multiple chronic diseases.

How does glutathione fight anxiety?

Low levels of glutathione have been linked to an increased risk of anxiety and depression (22). The reason is that oxidative stress is extremely damaging to the brain and can impact its functioning (23).

­How to Take Glutathione

Surprisingly, glutathione supplements haven’t been demonstrated effective in raising glutathione levels in the body because it is broken down into other amino acids during digestion.

But, several other supplements may increase glutathione levels naturally.

These other options include:

Green leafy vegetables, garlic, and meat may also increase glutathione.

There are no major detrimental side effects reported from taking glutathione supplements.

Video: Best Anti-Anxiety Supplements

Recap on Anxiety Reducing Supplements

Anxiety symptoms may come and go depending on what is going on in your life. But, if your anxiety is impacting your relationships and your ability to function you may want to seek medical treatment.

Severe anxiety disorders usually need professional treatment by a therapist, psychiatrist, or medical doctor.

If you are taking medications for your anxiety, you will want to check with your doctor before using any dietary supplements as there may be interactions

Regardless of the severity of your anxiety, certain lifestyle treatments have shown to be very beneficial.

Stress management, meditation, yoga, regular relaxation, and exercise can help reduce anxiety.

Positive visualization and cognitive activities can be used to replace negative or anxiety-producing thoughts and beliefs. Avoiding excessive caffeine or alcohol intake can also make anxiety management easier.

Finally, a strong support network with friends and family can ease some symptoms.

A well-rounded treatment for anxiety should involve a combination of different approaches to help you live your best and most relaxed life.

Keep Reading: 5 Natural Supplements for Your Brain Health

ⓘ Any specific supplement products & brands featured on this website are not necessarily endorsed by Ana.

Stock Photos from Marcos Mesa Sam Wordley / Zivica Kerkez / Shutterstock

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